[1] FLA Panthers 5-3 BUF Sabres [6] 2022-04-03 17:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Andrew Brunette
Head to Head
| NHL | 2022/03/08 00:00 | FLA Panthers v BUF Sabres | W | 6-1 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | W | 4-7 |
| NHL | 2020/01/04 18:00 | FLA Panthers v BUF Sabres | L | 2-3 |
| NHL | 2019/11/24 22:00 | BUF Sabres v FLA Panthers | L | 5-2 |
| NHL | 2019/10/11 23:00 | FLA Panthers v BUF Sabres | L | 2-3 |
| NHL | 2019/02/20 00:00 | BUF Sabres v FLA Panthers | W | 2-4 |
| NHL | 2019/01/04 00:00 | FLA Panthers v BUF Sabres | L | 3-4 |
| NHL | 2018/12/19 00:00 | FLA Panthers v BUF Sabres | W | 5-2 |
Home History
| NHL | 2022/04/02 16:30 | FLA Panthers v NJ Devils | W | 7-6 |
| NHL | 2022/03/31 23:00 | CHI Blackhawks v FLA Panthers | W | 0-4 |
| NHL | 2022/03/29 23:00 | MON Canadiens v FLA Panthers | W | 4-7 |
| NHL | 2022/03/27 23:00 | FLA Panthers v TOR Maple Leafs | L | 2-5 |
| NHL | 2022/03/26 23:00 | FLA Panthers v OTT Senators | W | 4-3 |
| NHL | 2022/03/24 23:00 | FLA Panthers v MON Canadiens | W | 4-3 |
| NHL | 2022/03/19 02:00 | FLA Panthers v ANA Ducks | W | 3-0 |
| NHL | 2022/03/18 02:30 | FLA Panthers v VGS Golden Knights | L | 3-5 |
Away History
| NHL | 2022/04/01 23:00 | NAS Predators v BUF Sabres | W | 3-4 |
| NHL | 2022/03/30 23:00 | WIN Jets v BUF Sabres | L | 3-2 |
| NHL | 2022/03/29 00:30 | BUF Sabres v CHI Blackhawks | W | 6-5 |
| NHL | 2022/03/27 21:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2022/03/25 23:00 | WAS Capitals v BUF Sabres | L | 4-3 |
| NHL | 2022/03/23 23:30 | PIT Penguins v BUF Sabres | W | 3-4 |
| NHL | 2022/03/21 02:00 | BUF Sabres v VAN Canucks | W | 3-2 |
| NHL | 2022/03/19 01:00 | BUF Sabres v CAL Flames | W | 1-0 |