Stadium: Moore Gymnasium
Home Manager: Reggie Theus Away Manager: Sean Woods
| NCAAB | 2022/01/08 21:00 | Southern v Florida A&M | W | 80-66 |
| NCAAB | 2022/01/04 01:30 | Texas Southern v Southern | W | 50-63 |
| NCAAB | 2021/12/22 00:00 | Southern v Dayton | L | 60-69 |
| NCAAB | 2021/12/19 22:30 | Southern v Kent State | W | 78-76 |
| NCAAB | 2021/12/11 23:30 | SE Louisiana v Southern | W | 66-72 |
| NCAAB | 2021/12/10 01:00 | Southern v Lindsey Wilson College | W | 86-68 |
| NCAAB | 2021/12/08 00:00 | Southern v Kentucky | L | 64-76 |
| NCAAB | 2021/12/05 00:00 | Southern v Akron | L | 62-79 |
| NCAAB | 2022/01/08 22:30 | Grambling State v Bethune Cookman | L | 68-66 |
| NCAAB | 2022/01/05 18:00 | Bethune Cookman v Florida Intl | L | 65-68 |
| NCAAB | 2022/01/03 23:30 | Florida A&M v Bethune Cookman | W | 59-66 |
| NCAAB | 2021/12/23 00:00 | Bethune Cookman v Marist | L | 45-68 |
| NCAAB | 2021/12/16 00:05 | Bethune Cookman v Johnson U (Fla) | W | 88-41 |
| NCAAB | 2021/12/09 23:30 | Bethune Cookman v NC State | L | 48-65 |
| NCAAB | 2021/12/05 19:00 | Bethune Cookman v Central Florida | L | 45-81 |
| NCAAB | 2021/11/28 17:00 | Bethune Cookman v Seton Hall | L | 70-84 |