Head to Head
| Ghana FA Cup | 2021/08/01 18:00 | Hearts of Oak v Medeama SC | L | 3-0 |
| Ghana Premier League | 2021/06/13 18:00 | Hearts of Oak v Medeama SC | L | 2-0 |
| Ghana Premier League | 2021/02/04 15:00 | Medeama SC v Hearts of Oak | W | 1-0 |
| Ghana Premier League | 2020/01/05 15:00 | Medeama SC v Hearts of Oak | W | 3-0 |
| Ghana Premier League | 2018/06/03 15:00 | Hearts of Oak v Medeama SC | D | 1-1 |
| Ghana Premier League | 2017/10/15 15:00 | Medeama SC v Hearts of Oak | W | 1-0 |
| Ghana Premier League | 2017/02/19 15:00 | Hearts of Oak v Medeama SC | D | 0-0 |
| Ghana Premier League | 2016/09/14 15:00 | Hearts of Oak v Medeama SC | W | 0-1 |
Home History
| Ghana Premier League | 2022/01/07 15:00 | Medeama SC v Berekum Chelsea | D | 1-1 |
| Ghana Premier League | 2022/01/03 15:00 | Ashanti Gold v Medeama SC | W | 0-1 |
| Ghana FA Cup | 2021/12/29 15:00 | Karela United FC v Medeama SC | L | 7-6 |
| Ghana Premier League | 2021/12/26 15:00 | Medeama SC v Aduana Stars | W | 1-0 |
| Ghana Premier League | 2021/12/19 15:00 | WAFA v Medeama SC | L | 1-0 |
| Ghana Premier League | 2021/12/15 15:00 | Medeama SC v Legon Cities FC | W | 1-0 |
| Ghana Premier League | 2021/12/12 15:00 | Real Tamale United v Medeama SC | W | 0-1 |
| Ghana Premier League | 2021/11/28 15:00 | King Faisal v Medeama SC | D | 0-0 |
Away History
| Ghana Premier League | 2022/01/08 15:00 | Bibiani Gold Stars v Hearts of Oak | W | 0-1 |
| Ghana Premier League | 2022/01/02 15:00 | Hearts of Oak v Bechem FC | D | 0-0 |
| Ghana Premier League | 2021/12/29 15:00 | Hearts of Oak v Berekum Chelsea | W | 2-0 |
| Ghana Premier League | 2021/12/25 15:00 | Dreams v Hearts of Oak | D | 2-2 |
| Ghana Premier League | 2021/12/19 18:00 | Hearts of Oak v Accra Lions FC | W | 2-0 |
| Ghana Premier League | 2021/12/15 15:00 | Elmina Sharks v Hearts of Oak | W | 0-1 |
| CAF Confederations Cup | 2021/12/05 16:45 | JS Saoura v Hearts of Oak | L | 4-0 |
| CAF Confederations Cup | 2021/11/28 15:00 | Hearts of Oak v JS Saoura | W | 2-0 |