[6] BUF Sabres 5-2 TOR Maple Leafs [2] 2022-04-12 23:00
Stadium: Scotiabank Arena
Home Manager: Sheldon Keefe Away Manager: Don Granato
Head to Head
| NHL | 2022/03/13 20:00 | TOR Maple Leafs v BUF Sabres | W | 2-5 |
| NHL | 2022/03/03 00:30 | BUF Sabres v TOR Maple Leafs | W | 5-1 |
| NHL | 2021/11/14 00:00 | TOR Maple Leafs v BUF Sabres | L | 5-4 |
| NHL | 2020/02/17 00:00 | TOR Maple Leafs v BUF Sabres | W | 2-5 |
| NHL | 2019/12/18 00:00 | BUF Sabres v TOR Maple Leafs | L | 3-5 |
| NHL | 2019/12/01 00:00 | BUF Sabres v TOR Maple Leafs | L | 1-2 |
| NHL | 2019/11/29 21:00 | TOR Maple Leafs v BUF Sabres | W | 4-6 |
| NHL Pre-Season | 2019/09/21 23:00 | TOR Maple Leafs v BUF Sabres | W | 3-5 |
Home History
| NHL | 2022/04/10 21:00 | BUF Sabres v TB Lightning | L | 0-5 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2022/04/07 23:30 | BUF Sabres v CAR Hurricanes | L | 3-5 |
| NHL | 2022/04/05 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/04/01 23:00 | NAS Predators v BUF Sabres | W | 3-4 |
| NHL | 2022/03/30 23:00 | WIN Jets v BUF Sabres | L | 3-2 |
| NHL | 2022/03/29 00:30 | BUF Sabres v CHI Blackhawks | W | 6-5 |
Away History
| NHL | 2022/04/09 23:00 | MON Canadiens v TOR Maple Leafs | W | 2-3 |
| NHL | 2022/04/08 00:30 | TOR Maple Leafs v DAL Stars | W | 4-3 |
| NHL | 2022/04/05 23:00 | TOR Maple Leafs v FLA Panthers | L | 6-7 |
| NHL | 2022/04/04 23:30 | TOR Maple Leafs v TB Lightning | W | 6-2 |
| NHL | 2022/04/02 23:00 | TOR Maple Leafs v PHI Flyers | W | 6-3 |
| NHL | 2022/03/31 23:00 | WIN Jets v TOR Maple Leafs | W | 3-7 |
| NHL | 2022/03/29 23:00 | TOR Maple Leafs v BOS Bruins | W | 6-4 |
| NHL | 2022/03/27 23:00 | FLA Panthers v TOR Maple Leafs | W | 2-5 |