[6] BUF Sabres 0-5 TB Lightning [4] 2022-04-10 21:00
Stadium: Amalie Arena
Home Manager: Jon Cooper Away Manager: Don Granato
Head to Head
| NHL | 2022/01/12 00:00 | TB Lightning v BUF Sabres | L | 6-1 |
| NHL | 2021/10/25 23:00 | TB Lightning v BUF Sabres | W | 1-5 |
| NHL | 2020/01/01 00:00 | TB Lightning v BUF Sabres | L | 6-4 |
| NHL | 2019/11/26 00:00 | BUF Sabres v TB Lightning | L | 2-5 |
| NHL | 2019/11/09 18:00 | BUF Sabres v TB Lightning | L | 3-5 |
| NHL | 2019/11/08 19:00 | TB Lightning v BUF Sabres | L | 3-2 |
| NHL | 2019/02/22 00:30 | BUF Sabres v TB Lightning | L | 1-2 |
| NHL | 2019/01/13 00:00 | TB Lightning v BUF Sabres | L | 5-3 |
Home History
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2022/04/07 23:30 | BUF Sabres v CAR Hurricanes | L | 3-5 |
| NHL | 2022/04/05 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/04/01 23:00 | NAS Predators v BUF Sabres | W | 3-4 |
| NHL | 2022/03/30 23:00 | WIN Jets v BUF Sabres | L | 3-2 |
| NHL | 2022/03/29 00:30 | BUF Sabres v CHI Blackhawks | W | 6-5 |
| NHL | 2022/03/27 21:00 | BUF Sabres v NY Rangers | L | 4-5 |
Away History
| NHL | 2022/04/08 23:00 | BOS Bruins v TB Lightning | L | 2-1 |
| NHL | 2022/04/06 23:30 | TB Lightning v WAS Capitals | L | 3-4 |
| NHL | 2022/04/04 23:30 | TOR Maple Leafs v TB Lightning | L | 6-2 |
| NHL | 2022/04/02 23:00 | MON Canadiens v TB Lightning | L | 5-4 |
| NHL | 2022/04/01 23:00 | CHI Blackhawks v TB Lightning | W | 2-5 |
| NHL | 2022/03/29 23:00 | CAR Hurricanes v TB Lightning | W | 3-4 |
| NHL | 2022/03/27 18:00 | TB Lightning v NY Islanders | W | 4-1 |
| NHL | 2022/03/26 16:30 | TB Lightning v DET Red Wings | W | 2-1 |