[3] TOR Maple Leafs 5-4 OTT Senators [13] 2022-04-16 23:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Sheldon Keefe
Head to Head
| NHL | 2022/01/02 00:00 | OTT Senators v TOR Maple Leafs | W | 0-6 |
| NHL | 2021/10/16 23:00 | OTT Senators v TOR Maple Leafs | W | 1-3 |
| NHL | 2021/10/14 23:00 | TOR Maple Leafs v OTT Senators | L | 2-3 |
| NHL Pre-Season | 2021/10/09 23:00 | OTT Senators v TOR Maple Leafs | W | 1-4 |
| NHL Pre-Season | 2021/10/04 23:00 | TOR Maple Leafs v OTT Senators | W | 3-1 |
| NHL Pre-Season | 2021/09/29 23:00 | TOR Maple Leafs v OTT Senators | W | 4-0 |
| NHL | 2021/05/13 00:00 | TOR Maple Leafs v OTT Senators | L | 3-4 |
| NHL | 2021/04/10 23:00 | OTT Senators v TOR Maple Leafs | W | 5-6 |
Home History
| NHL | 2022/04/14 23:00 | WAS Capitals v TOR Maple Leafs | W | 3-7 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | L | 5-2 |
| NHL | 2022/04/09 23:00 | MON Canadiens v TOR Maple Leafs | W | 2-3 |
| NHL | 2022/04/08 00:30 | TOR Maple Leafs v DAL Stars | W | 4-3 |
| NHL | 2022/04/05 23:00 | TOR Maple Leafs v FLA Panthers | L | 6-7 |
| NHL | 2022/04/04 23:30 | TOR Maple Leafs v TB Lightning | W | 6-2 |
| NHL | 2022/04/02 23:00 | TOR Maple Leafs v PHI Flyers | W | 6-3 |
| NHL | 2022/03/31 23:00 | WIN Jets v TOR Maple Leafs | W | 3-7 |
Away History
| NHL | 2022/04/14 23:00 | OTT Senators v BOS Bruins | W | 3-2 |
| NHL | 2022/04/12 23:30 | OTT Senators v DET Red Wings | W | 4-1 |
| NHL | 2022/04/10 23:30 | WIN Jets v OTT Senators | L | 4-3 |
| NHL | 2022/04/09 23:00 | OTT Senators v NY Rangers | L | 1-5 |
| NHL | 2022/04/07 23:00 | NAS Predators v OTT Senators | L | 3-2 |
| NHL | 2022/04/05 23:00 | OTT Senators v MON Canadiens | W | 6-3 |
| NHL | 2022/04/03 17:00 | DET Red Wings v OTT Senators | W | 2-5 |
| NHL | 2022/04/01 23:30 | OTT Senators v DET Red Wings | W | 5-2 |