Head to Head
| NCAAF | 2014/09/06 23:00 | Louisville v Murray State | L | 66-21 |
| NCAAF | 2011/09/01 12:00 | Louisville v Murray State | L | 21-9 |
| NCAAF | 2007/08/30 12:00 | Louisville v Murray State | L | 73-10 |
Home History
| NCAAF | 2017/09/23 23:00 | Murray State v Austin Peay | L | 7-27 |
| NCAAF | 2017/09/16 19:00 | Missouri St v Murray State | L | 28-21 |
| NCAAF | 2017/09/09 23:00 | Murray State v Central Arkansas | L | 13-41 |
| NCAAF | 2017/08/31 23:00 | Murray State v Kentucky Wesleyan | W | 67-7 |
| NCAAF | 2016/09/03 19:30 | Illinois v Murray State | L | 52-3 |
| NCAAF | 2015/09/19 23:00 | Western Michigan v Murray State | L | 52-20 |
| NCAAF | 2015/09/12 19:30 | Northern Illinois v Murray State | L | 57-26 |
| NCAAF | 2014/09/20 23:00 | Western Michigan v Murray State | L | 45-14 |
Away History
| NCAAF | 2017/09/23 18:00 | Kent State v Louisville | W | 3-42 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | L | 47-21 |
| NCAAF | 2017/09/09 16:00 | Louisville v North Carolina | W | 47-35 |
| NCAAF | 2017/09/02 23:36 | Louisville v Purdue | W | 35-28 |
| NCAAF | 2017/09/02 23:30 | Purdue v Louisville | W | 28-35 |
| NCAAF | 2016/12/31 16:00 | LSU v Louisville | L | 29-9 |
| NCAAF | 2016/11/26 17:00 | Kentucky v Louisville | L | 41-38 |
| NCAAF | 2016/11/18 01:00 | Louisville v Houston | L | 10-36 |