[15] PHI Flyers 3-4 BUF Sabres [6] 2022-04-16 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Yeo
Head to Head
| NHL | 2022/01/22 18:00 | PHI Flyers v BUF Sabres | L | 3-6 |
| NHL | 2021/04/11 18:00 | BUF Sabres v PHI Flyers | L | 5-3 |
| NHL | 2021/03/31 23:30 | PHI Flyers v BUF Sabres | L | 1-6 |
| NHL | 2021/03/29 23:00 | PHI Flyers v BUF Sabres | W | 4-3 |
| NHL | 2021/03/10 00:00 | BUF Sabres v PHI Flyers | W | 4-5 |
| NHL | 2021/02/28 20:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/02/27 18:00 | PHI Flyers v BUF Sabres | W | 3-0 |
| NHL | 2021/01/20 00:00 | BUF Sabres v PHI Flyers | W | 0-3 |
Home History
| NHL | 2022/04/13 23:00 | NY Rangers v PHI Flyers | L | 4-0 |
| NHL | 2022/04/12 23:00 | PHI Flyers v WAS Capitals | L | 2-9 |
| NHL | 2022/04/09 23:30 | ANA Ducks v PHI Flyers | L | 5-3 |
| NHL | 2022/04/07 23:00 | PHI Flyers v CLB Blue Jackets | W | 4-1 |
| NHL | 2022/04/05 23:00 | CLB Blue Jackets v PHI Flyers | L | 4-2 |
| NHL | 2022/04/03 23:00 | PHI Flyers v NY Rangers | W | 4-3 |
| NHL | 2022/04/02 23:00 | TOR Maple Leafs v PHI Flyers | L | 6-3 |
| NHL | 2022/03/30 00:00 | PHI Flyers v MIN Wild | L | 1-4 |
Away History
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
| NHL | 2022/04/10 21:00 | BUF Sabres v TB Lightning | L | 0-5 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2022/04/07 23:30 | BUF Sabres v CAR Hurricanes | L | 3-5 |
| NHL | 2022/04/05 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/04/01 23:00 | NAS Predators v BUF Sabres | W | 3-4 |