[5] DET Red Wings 2-5 FLA Panthers [1] 2022-04-21 23:00
Stadium: Amerant Bank Arena
Home Manager: Andrew Brunette Away Manager: Jeff Blashill
Head to Head
| NHL | 2022/04/17 17:00 | FLA Panthers v DET Red Wings | L | 6-1 |
| NHL | 2022/03/05 23:00 | DET Red Wings v FLA Panthers | L | 2-6 |
| NHL | 2021/10/29 23:00 | FLA Panthers v DET Red Wings | L | 3-2 |
| NHL | 2021/04/01 23:00 | DET Red Wings v FLA Panthers | L | 2-3 |
| NHL | 2021/03/30 23:00 | DET Red Wings v FLA Panthers | L | 1-4 |
| NHL | 2021/02/20 22:00 | FLA Panthers v DET Red Wings | W | 1-2 |
| NHL | 2021/02/20 00:00 | FLA Panthers v DET Red Wings | L | 7-2 |
| NHL | 2021/02/10 00:00 | DET Red Wings v FLA Panthers | L | 1-2 |
Home History
| NHL | 2022/04/19 23:00 | DET Red Wings v TB Lightning | W | 4-3 |
| NHL | 2022/04/17 17:00 | FLA Panthers v DET Red Wings | L | 6-1 |
| NHL | 2022/04/16 16:30 | DET Red Wings v NY Rangers | L | 0-4 |
| NHL | 2022/04/14 23:00 | DET Red Wings v CAR Hurricanes | W | 3-0 |
| NHL | 2022/04/12 23:30 | OTT Senators v DET Red Wings | L | 4-1 |
| NHL | 2022/04/09 23:00 | CLB Blue Jackets v DET Red Wings | L | 5-4 |
| NHL | 2022/04/06 23:30 | DET Red Wings v WIN Jets | W | 3-1 |
| NHL | 2022/04/05 23:30 | BOS Bruins v DET Red Wings | W | 3-5 |
Away History
| NHL | 2022/04/19 23:30 | FLA Panthers v NY Islanders | W | 3-2 |
| NHL | 2022/04/17 17:00 | FLA Panthers v DET Red Wings | W | 6-1 |
| NHL | 2022/04/15 23:00 | WIN Jets v FLA Panthers | W | 1-6 |
| NHL | 2022/04/12 23:00 | ANA Ducks v FLA Panthers | W | 2-3 |
| NHL | 2022/04/09 22:00 | FLA Panthers v NAS Predators | W | 4-1 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | W | 3-4 |
| NHL | 2022/04/05 23:00 | TOR Maple Leafs v FLA Panthers | W | 6-7 |
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | W | 5-3 |