[14] Penarol 0-1 Defensor Sporting [15] 2022-02-13 23:00
Stadium: Estadio Campeon del Siglo Round: 2
Referee: Andres Matonte Home Manager: Mauricio Larriera Away Manager: Eduardo Mario Acevedo Cardozo
Head to Head
| Uruguay Clausura | 2021/01/28 00:00 | Penarol v Defensor Sporting | L | 1-2 |
| Uruguay Torneo Intermedio | 2020/11/01 21:00 | Defensor Sporting v Penarol | L | 2-1 |
| Uruguay Apertura | 2020/02/23 22:30 | Defensor Sporting v Penarol | L | 2-1 |
| Uruguay Clausura | 2019/09/14 22:00 | Penarol v Defensor Sporting | W | 1-0 |
| Uruguay Torneo Intermedio | 2019/08/11 21:00 | Defensor Sporting v Penarol | D | 2-2 |
| Uruguay Apertura | 2019/02/17 22:30 | Defensor Sporting v Penarol | W | 0-1 |
| Uruguay Clausura | 2018/11/04 19:30 | Defensor Sporting v Penarol | W | 1-2 |
| Uruguay Torneo Intermedio | 2018/06/07 18:00 | Defensor Sporting v Penarol | W | 1-3 |
Home History
| Uruguay Apertura | 2022/02/05 20:00 | Atletico Fenix Montevideo v Penarol | L | 1-0 |
| Uruguay Supercopa | 2022/01/30 22:00 | Plaza Colonia v Penarol | D | 0-0 |
| Club Friendly List | 2022/01/26 22:00 | Penarol v Nacional De Football | W | 1-0 |
| America Friendlies | 2022/01/25 00:30 | Penarol v Santiago Wanderers | W | 2-0 |
| America Friendlies | 2022/01/20 00:30 | Penarol v Nublense | W | 1-0 |
| Club Friendly List | 2022/01/17 22:15 | Penarol v Barracas Central | W | 4-0 |
| Uruguay Clausura | 2021/12/07 23:30 | Plaza Colonia v Penarol | D | 1-1 |
| Uruguay Clausura | 2021/12/04 20:00 | Penarol v IA Sud America | W | 3-1 |
Away History
| Uruguay Apertura | 2022/02/05 22:30 | Defensor Sporting v Liverpool Montevideo | L | 0-3 |
| Club Friendly List | 2022/01/29 22:15 | Defensor Sporting v Estudiantes LP | L | 1-4 |
| America Friendlies | 2022/01/19 00:30 | Defensor Sporting v Union Espanola | L | 0-2 |
| America Friendlies | 2022/01/17 00:30 | Defensor Sporting v Danubio | L | 0-2 |
| Uruguay Segunda | 2021/12/09 23:30 | Racing Club de Montevideo v Defensor Sporting | D | 0-0 |
| Uruguay Segunda | 2021/12/07 00:45 | Defensor Sporting v Racing Club de Montevideo | W | 3-0 |
| Uruguay Segunda | 2021/12/04 00:45 | Defensor Sporting v Cerro | L | 0-1 |
| Uruguay Segunda | 2021/11/30 22:00 | Cerro v Defensor Sporting | W | 1-2 |