[6] BUF Sabres 5-2 NJ Devils [14] 2022-04-21 23:00
Stadium: Prudential Center
Home Manager: Lindy Ruff Away Manager: Don Granato
Head to Head
| NHL | 2021/12/30 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/10/23 23:00 | BUF Sabres v NJ Devils | L | 1-2 |
| NHL | 2021/04/08 23:00 | NJ Devils v BUF Sabres | L | 6-3 |
| NHL | 2021/04/06 23:00 | BUF Sabres v NJ Devils | W | 5-3 |
| NHL | 2021/03/16 23:00 | BUF Sabres v NJ Devils | L | 2-3 |
| NHL | 2021/02/26 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/02/24 00:00 | BUF Sabres v NJ Devils | W | 4-1 |
| NHL | 2021/02/20 17:30 | BUF Sabres v NJ Devils | W | 3-2 |
Home History
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
| NHL | 2022/04/10 21:00 | BUF Sabres v TB Lightning | L | 0-5 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
| NHL | 2022/04/07 23:30 | BUF Sabres v CAR Hurricanes | L | 3-5 |
| NHL | 2022/04/05 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
Away History
| NHL | 2022/04/19 02:00 | NJ Devils v VGS Golden Knights | W | 3-2 |
| NHL | 2022/04/17 02:00 | NJ Devils v SEA Kraken | L | 3-4 |
| NHL | 2022/04/15 01:00 | NJ Devils v COL Avalanche | L | 1-3 |
| NHL | 2022/04/13 02:00 | NJ Devils v ARZ Coyotes | W | 6-2 |
| NHL | 2022/04/09 18:00 | NJ Devils v DAL Stars | W | 3-1 |
| NHL | 2022/04/07 23:00 | MON Canadiens v NJ Devils | L | 7-4 |
| NHL | 2022/04/05 23:00 | NY Rangers v NJ Devils | L | 3-1 |
| NHL | 2022/04/03 20:00 | NY Islanders v NJ Devils | L | 4-3 |