[5] BUF Sabres 0-5 BOS Bruins [4] 2022-04-28 23:00
Stadium: TD Garden
Home Manager: Bruce Cassidy Away Manager: Don Granato
Head to Head
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | L | 3-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | L | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | L | 2-5 |
| NHL | 2021/04/23 23:00 | BOS Bruins v BUF Sabres | W | 4-6 |
| NHL | 2021/04/22 23:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | L | 2-0 |
Home History
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | W | 3-5 |
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |
| NHL | 2022/04/16 23:00 | PHI Flyers v BUF Sabres | W | 3-4 |
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | L | 6-2 |
| NHL | 2022/04/12 23:00 | BUF Sabres v TOR Maple Leafs | W | 5-2 |
| NHL | 2022/04/10 21:00 | BUF Sabres v TB Lightning | L | 0-5 |
| NHL | 2022/04/08 23:00 | BUF Sabres v FLA Panthers | L | 3-4 |
Away History
| NHL | 2022/04/26 23:00 | FLA Panthers v BOS Bruins | W | 2-4 |
| NHL | 2022/04/24 23:00 | BOS Bruins v MON Canadiens | W | 5-3 |
| NHL | 2022/04/23 19:00 | NY Rangers v BOS Bruins | W | 1-3 |
| NHL | 2022/04/21 23:00 | BOS Bruins v PIT Penguins | L | 0-4 |
| NHL | 2022/04/20 00:00 | BOS Bruins v STL Blues | W | 3-2 |
| NHL | 2022/04/16 16:30 | PIT Penguins v BOS Bruins | W | 1-2 |
| NHL | 2022/04/14 23:00 | OTT Senators v BOS Bruins | L | 3-2 |
| NHL | 2022/04/12 23:00 | STL Blues v BOS Bruins | L | 4-2 |