| Colombia Regional League | 2021/12/05 17:15 | E.D.P IND. Medellin v Ferrovalvulas FC | L | 0-2 |
| Colombia Regional League | 2021/11/12 23:10 | E.D.P IND. Medellin v Politecnico J.I.C. | W | 1-0 |
| Colombia Regional League | 2021/10/24 17:15 | Deportivo Alexis Garcia v E.D.P IND. Medellin | D | 0-0 |
| Colombia Regional League | 2021/09/17 16:00 | Sellos Colombianos v E.D.P IND. Medellin | W | 3-5 |
| Colombia Regional League | 2021/08/21 21:10 | Sol de Oriente v E.D.P IND. Medellin | L | 2-1 |
| Colombia Regional League | 2021/07/02 17:11 | Club Deportivo La Chalaca v E.D.P IND. Medellin | W | 0-2 |
| Colombia Regional League | 2021/06/27 17:15 | E.D.P IND. Medellin v Estudiantes de Medellin | L | 0-1 |
| Colombia Regional League | 2021/03/26 16:19 | Estudiantes de Medellin v E.D.P IND. Medellin | W | 0-1 |
| Colombia Regional League | 2021/10/06 15:13 | Real Santuario v Inder Girardota | W | 5-0 |
| Colombia Primera C | 2021/09/02 17:10 | Antioquia FC v Real Santuario | W | 2-3 |
| Colombia Regional League | 2021/08/28 01:06 | Politecnico J.I.C. v Real Santuario | L | 2-1 |
| Colombia Primera C | 2021/08/26 17:00 | Politecnico J.I.C. v Real Santuario | L | 2-1 |
| Colombia Regional League | 2021/08/22 17:00 | Real Santuario v Deportivo Alexis Garcia | W | 2-1 |
| Colombia Primera C | 2021/08/10 17:00 | Real Santuario v Antioquia FC | L | 1-3 |
| Colombia Regional League | 2021/07/18 19:21 | CD Gallegol v Real Santuario | L | 3-2 |
| Colombia Regional League | 2021/07/04 17:16 | CD Los Del Sur v Real Santuario | W | 2-4 |