Stadium: Gainbridge Fieldhouse Round: 2
Home Manager: Matt Painter Away Manager: Tom Izzo
| NCAAB | 2022/02/26 17:00 | Purdue v Michigan State | W | 65-68 |
| NCAAB | 2021/02/17 00:00 | Michigan State v Purdue | L | 65-75 |
| NCAAB | 2021/01/09 00:00 | Purdue v Michigan State | L | 55-54 |
| NCAAB | 2020/01/12 17:00 | Michigan State v Purdue | L | 42-71 |
| NCAAB | 2019/01/27 18:00 | Michigan State v Purdue | L | 63-73 |
| NCAAB | 2019/01/09 02:00 | Purdue v Michigan State | W | 59-77 |
| NCAAB | 2018/02/10 21:00 | Purdue v Michigan State | W | 65-68 |
| NCAAB | 2017/02/18 21:00 | Michigan State v Purdue | L | 63-80 |
| NCAAB | 2022/03/11 23:30 | Michigan State v Wisconsin | W | 69-63 |
| NCAAB | 2022/03/10 23:30 | Maryland v Michigan State | W | 72-76 |
| NCAAB | 2022/03/06 21:30 | Maryland v Michigan State | W | 67-77 |
| NCAAB | 2022/03/04 00:00 | Michigan State v Ohio State | L | 69-80 |
| NCAAB | 2022/03/02 01:30 | Michigan State v Michigan | L | 70-87 |
| NCAAB | 2022/02/26 17:00 | Purdue v Michigan State | W | 65-68 |
| NCAAB | 2022/02/23 00:00 | Michigan State v Iowa | L | 60-86 |
| NCAAB | 2022/02/19 17:00 | Illinois v Michigan State | L | 79-74 |
| NCAAB | 2022/03/12 02:00 | Penn State v Purdue | W | 61-69 |
| NCAAB | 2022/03/05 19:00 | Indiana v Purdue | W | 67-69 |
| NCAAB | 2022/03/02 02:00 | Purdue v Wisconsin | L | 67-70 |
| NCAAB | 2022/02/26 17:00 | Purdue v Michigan State | L | 65-68 |
| NCAAB | 2022/02/20 22:30 | Rutgers v Purdue | W | 72-84 |
| NCAAB | 2022/02/17 02:00 | Purdue v Northwestern | W | 70-64 |
| NCAAB | 2022/02/13 18:00 | Maryland v Purdue | W | 61-62 |
| NCAAB | 2022/02/11 02:00 | Purdue v Michigan | L | 58-82 |