Stadium: Mitchell Center Round: 3
Home Manager: Richie Riley Away Manager: Dave Dickerson
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | W | 80-74 |
| NCAAB | 2022/03/05 17:00 | USC Upstate v Longwood | L | 70-79 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/26 21:00 | Gardner Webb v USC Upstate | W | 70-72 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | L | 59-89 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | W | 78-73 |
| NCAAB | 2022/02/16 23:00 | Presbyterian v USC Upstate | W | 55-60 |
| NCAAB | 2022/02/12 21:00 | UNC Asheville v USC Upstate | L | 83-56 |
| NCAAB | 2022/03/17 00:00 | SE Louisiana v South Alabama | W | 68-70 |
| NCAAB | 2022/03/03 20:00 | Arkansas LR v South Alabama | L | 75-71 |
| NCAAB | 2022/02/26 20:00 | UT Arlington v South Alabama | W | 52-62 |
| NCAAB | 2022/02/24 01:00 | Texas State v South Alabama | L | 55-52 |
| NCAAB | 2022/02/19 21:30 | South Alabama v Appalachian State | L | 51-69 |
| NCAAB | 2022/02/18 00:00 | South Alabama v Coastal Carolina | W | 71-68 |
| NCAAB | 2022/02/13 00:00 | Arkansas State v South Alabama | W | 51-70 |
| NCAAB | 2022/02/11 01:00 | Arkansas LR v South Alabama | W | 46-77 |