[5] San German 81-83 Santurce [4] 2022-04-22 00:00
Stadium: Arquelio Torres Ramirez Coliseum Round: 1
Head to Head
| Puerto Rico Superior Nacional | 2021/09/07 00:00 | San German v Santurce | L | 85-90 |
| Puerto Rico Superior Nacional | 2021/07/30 00:00 | Santurce v San German | L | 92-71 |
Home History
| Puerto Rico Superior Nacional | 2022/04/20 00:00 | San German v Quebradillas | L | 55-62 |
| Puerto Rico Superior Nacional | 2022/04/17 22:00 | Humacao v San German | L | 93-82 |
| Puerto Rico Superior Nacional | 2022/04/15 00:00 | Vaqueros de Bayamon v San German | L | 77-65 |
| Puerto Rico Superior Nacional | 2022/04/13 00:00 | San German v Ponce | W | 82-81 |
| Puerto Rico Superior Nacional | 2021/10/06 00:00 | San German v Mayaguez | W | 103-96 |
| Puerto Rico Superior Nacional | 2021/10/02 00:00 | San German v Quebradillas | W | 110-101 |
| Puerto Rico Superior Nacional | 2021/09/30 00:00 | Arecibo v San German | L | 108-90 |
| Puerto Rico Superior Nacional | 2021/09/28 00:00 | Fajardo v San German | L | 105-94 |
Away History
| Puerto Rico Superior Nacional | 2022/04/20 00:00 | Santurce v Guaynabo | W | 73-68 |
| Puerto Rico Superior Nacional | 2022/04/17 00:00 | Vaqueros de Bayamon v Santurce | L | 101-98 |
| Puerto Rico Superior Nacional | 2022/04/15 00:00 | Santurce v Fajardo | L | 75-89 |
| Puerto Rico Superior Nacional | 2022/04/14 00:00 | Santurce v Guayama | W | 73-63 |
| Basketball Champions League Americas | 2022/04/06 15:30 | Santurce v Quimsa | L | 79-87 |
| Basketball Champions League Americas | 2022/03/16 01:30 | Santurce v Real Esteli | L | 83-96 |
| Basketball Champions League Americas | 2022/03/15 01:30 | Edmonton Stingers v Santurce | L | 93-87 |
| Basketball Champions League Americas | 2022/03/06 01:00 | Santurce v Edmonton Stingers | W | 93-55 |