| Colombia Regional League | 2021/08/22 17:00 | Real Santuario v Deportivo Alexis Garcia | W | 2-1 |
| Colombia Regional League | 2022/03/01 17:13 | E.D.P IND. Medellin v Real Santuario | L | 2-0 |
| Colombia Regional League | 2021/10/06 15:13 | Real Santuario v Inder Girardota | W | 5-0 |
| Colombia Primera C | 2021/09/02 17:10 | Antioquia FC v Real Santuario | W | 2-3 |
| Colombia Regional League | 2021/08/28 01:06 | Politecnico J.I.C. v Real Santuario | L | 2-1 |
| Colombia Primera C | 2021/08/26 17:00 | Politecnico J.I.C. v Real Santuario | L | 2-1 |
| Colombia Regional League | 2021/08/22 17:00 | Real Santuario v Deportivo Alexis Garcia | W | 2-1 |
| Colombia Primera C | 2021/08/10 17:00 | Real Santuario v Antioquia FC | L | 1-3 |
| Colombia Regional League | 2021/07/18 19:21 | CD Gallegol v Real Santuario | L | 3-2 |
| Colombia Regional League | 2022/03/21 17:18 | Deportivo Alexis Garcia v Universidad de Antioquia | W | 3-0 |
| Colombia Regional League | 2021/12/04 17:17 | Deportivo Alexis Garcia v CD Gallegol | W | 3-2 |
| Colombia Regional League | 2021/11/27 19:24 | Atletico Nacional Medellin Reserves v Deportivo Alexis Garcia | L | 2-0 |
| Colombia Regional League | 2021/11/17 19:13 | Deportivo Alexis Garcia v CD Gallegol | D | 0-0 |
| Colombia Regional League | 2021/10/24 17:15 | Deportivo Alexis Garcia v E.D.P IND. Medellin | D | 0-0 |
| Colombia Regional League | 2021/08/29 17:23 | Deportivo Alexis Garcia v Envigado FC Reserves | L | 1-2 |
| Colombia Regional League | 2021/08/22 17:00 | Real Santuario v Deportivo Alexis Garcia | L | 2-1 |
| Colombia Regional League | 2021/07/16 17:17 | Club Deportivo La Chalaca v Deportivo Alexis Garcia | W | 1-2 |