| Uruguay Reserve League | 2021/08/17 18:00 | Deportivo Maldonado Reserves v Penarol Reserves | L | 1-0 |
| Uruguay Reserve League | 2022/03/22 19:00 | Danubio Reserves v Penarol Reserves | W | 0-2 |
| Uruguay Reserve League | 2022/03/14 19:30 | Penarol Reserves v Nacional de Montevideo Reserves | W | 1-0 |
| Uruguay Reserve League | 2022/03/01 13:00 | Albion FC Reserves v Penarol Reserves | W | 0-3 |
| Uruguay Reserve League | 2021/11/15 12:00 | Penarol Reserves v Sud America Reserves | W | 3-0 |
| Uruguay Reserve League | 2021/11/09 18:30 | Progreso Reserves v Penarol Reserves | L | 2-1 |
| Uruguay Reserve League | 2021/10/26 18:30 | Penarol Reserves v Cerro Largo Reserves | W | 2-0 |
| Uruguay Reserve League | 2021/10/18 18:30 | Atletico River Plate Reserves v Penarol Reserves | W | 0-5 |
| Uruguay Reserve League | 2021/10/04 18:30 | Penarol Reserves v Liverpool Montevideo Reserves | L | 0-1 |
| Uruguay Reserve League | 2022/03/22 19:00 | Deportivo Maldonado Reserves v Liverpool Montevideo Reserves | L | 2-3 |
| Uruguay Reserve League | 2022/03/15 19:30 | Rentistas Reserves v Deportivo Maldonado Reserves | L | 1-0 |
| Uruguay Reserve League | 2022/03/01 19:30 | Cerrito Reserves v Deportivo Maldonado Reserves | L | 2-1 |
| Uruguay Reserve League | 2022/02/22 19:30 | Deportivo Maldonado Reserves v Danubio Reserves | D | 1-1 |
| Uruguay Reserve League | 2021/11/15 19:00 | Boston River Reserves v Deportivo Maldonado Reserves | W | 0-2 |
| Uruguay Reserve League | 2021/11/09 18:30 | Deportivo Maldonado Reserves v Cerrito Reserves | W | 1-0 |
| Uruguay Reserve League | 2021/10/26 18:30 | Atletico Fenix Reserves v Deportivo Maldonado Reserves | L | 3-0 |
| Uruguay Reserve League | 2021/10/18 18:34 | Deportivo Maldonado Reserves v Nacional de Montevideo Reserves | L | 1-4 |