Home History
| USA MLS Next Pro League | 2022/06/05 00:00 | Chicago Fire II v Columbus Crew II | L | 2-4 |
| USA MLS Next Pro League | 2022/05/27 23:00 | Toronto FC II v Chicago Fire II | W | 2-6 |
| USA MLS Next Pro League | 2022/05/21 20:00 | New York City FC II v Chicago Fire II | L | 3-0 |
| USA MLS Next Pro League | 2022/05/15 22:00 | Chicago Fire II v FC Cincinnati II | W | 3-1 |
| USA MLS Next Pro League | 2022/05/08 21:00 | Chicago Fire II v Minnesota United FC II | L | 6-7 |
| USA MLS Next Pro League | 2022/04/24 23:00 | Chicago Fire II v Philadelphia Union II | W | 8-7 |
| USA MLS Next Pro League | 2022/04/17 18:00 | Toronto FC II v Chicago Fire II | L | 4-2 |
| USA MLS Next Pro League | 2022/04/10 19:30 | Chicago Fire II v RNY FC | L | 5-6 |
Away History
| USA MLS Next Pro League | 2022/06/09 01:00 | Colorado Rapids II v St Louis City II | W | 5-6 |
| USA MLS Next Pro League | 2022/06/05 00:00 | St Louis City II v Houston Dynamo II | W | 2-0 |
| USA MLS Next Pro League | 2022/05/30 00:00 | St Louis City II v The Town | L | 4-5 |
| USA MLS Next Pro League | 2022/05/23 00:00 | St Louis City II v Portland Timbers II | W | 3-1 |
| USA MLS Next Pro League | 2022/05/08 00:00 | St Louis City II v Vancouver Whitecaps II | L | 1-2 |
| USA MLS Next Pro League | 2022/04/30 01:00 | Real Monarchs SLC v St Louis City II | W | 0-2 |
| USA MLS Next Pro League | 2022/04/25 00:00 | St Louis City II v Minnesota United FC II | L | 0-4 |
| USA US Open Cup | 2022/04/20 23:30 | Louisville City FC v St Louis City II | L | 9-8 |