Head to Head
| MLB Spring Training | 2022/03/19 20:05 | CLE Guardians v CHI White Sox | L | 11-2 |
| MLB | 2021/09/26 17:10 | CHI White Sox v CLE Guardians | W | 5-2 |
| MLB | 2021/09/25 23:15 | CHI White Sox v CLE Guardians | L | 0-6 |
| MLB | 2021/09/24 23:10 | CHI White Sox v CLE Guardians | W | 1-0 |
| MLB | 2021/09/23 22:10 | CHI White Sox v CLE Guardians | L | 3-5 |
| MLB | 2021/09/23 17:10 | CHI White Sox v CLE Guardians | W | 7-2 |
| MLB | 2021/08/01 18:10 | CLE Guardians v CHI White Sox | W | 1-2 |
| MLB | 2021/07/31 23:10 | CLE Guardians v CHI White Sox | L | 12-11 |
Home History
| MLB | 2022/04/17 18:10 | TB Rays v CHI White Sox | L | 9-3 |
| MLB | 2022/04/16 18:10 | TB Rays v CHI White Sox | W | 2-3 |
| MLB | 2022/04/15 23:10 | TB Rays v CHI White Sox | W | 2-3 |
| MLB | 2022/04/14 18:10 | SEA Mariners v CHI White Sox | L | 5-1 |
| MLB | 2022/04/13 23:10 | SEA Mariners v CHI White Sox | W | 4-6 |
| MLB | 2022/04/12 20:10 | SEA Mariners v CHI White Sox | W | 2-3 |
| MLB | 2022/04/10 17:10 | CHI White Sox v DET Tigers | W | 10-1 |
| MLB | 2022/04/09 17:10 | CHI White Sox v DET Tigers | W | 5-2 |
Away History
| MLB | 2022/04/17 17:40 | SF Giants v CLE Guardians | L | 8-1 |
| MLB | 2022/04/16 22:10 | SF Giants v CLE Guardians | L | 4-2 |
| MLB | 2022/04/15 23:10 | SF Giants v CLE Guardians | L | 4-1 |
| MLB | 2022/04/13 16:35 | CLE Guardians v CIN Reds | W | 7-3 |
| MLB | 2022/04/12 20:10 | CLE Guardians v CIN Reds | W | 10-5 |
| MLB | 2022/04/11 18:10 | CLE Guardians v KC Royals | W | 10-7 |
| MLB | 2022/04/10 18:10 | CLE Guardians v KC Royals | W | 17-3 |
| MLB | 2022/04/09 20:10 | CLE Guardians v KC Royals | L | 0-1 |