Home History
| USA USL Championship | 2022/05/08 00:30 | Tulsa v Detroit City FC | L | 3-1 |
| USA USL Championship | 2022/04/30 20:00 | Detroit City FC v New York Red Bulls II | W | 2-0 |
| USA USL Championship | 2022/04/23 23:00 | Hartford Athletic v Detroit City FC | W | 1-2 |
| USA US Open Cup | 2022/04/19 23:30 | Detroit City FC v Columbus Crew | W | 2-1 |
| USA USL Championship | 2022/04/15 23:00 | Detroit City FC v Birmingham Legion FC | W | 1-0 |
| USA USL Championship | 2022/04/09 23:30 | Atlanta United II v Detroit City FC | W | 0-4 |
| USA US Open Cup | 2022/04/05 23:30 | Detroit City FC v Michigan Stars | W | 3-0 |
| USA USL Championship | 2022/04/02 20:00 | Detroit City FC v Memphis 901 FC | D | 1-1 |
Away History
| USA USL Championship | 2022/05/04 23:30 | Atlanta United II v Louisville City FC | W | 0-4 |
| USA USL Championship | 2022/04/30 23:30 | Louisville City FC v Pittsburgh Riverhounds | W | 2-0 |
| USA USL Championship | 2022/04/23 21:00 | Charleston Battery v Louisville City FC | D | 1-1 |
| USA US Open Cup | 2022/04/20 23:30 | Louisville City FC v St Louis City II | D | 0-0 |
| USA USL Championship | 2022/04/17 02:00 | San Diego Loyal v Louisville City FC | W | 2-5 |
| USA USL Championship | 2022/04/10 20:00 | Loudoun United FC v Louisville City FC | W | 0-2 |
| USA US Open Cup | 2022/04/06 23:30 | Louisville City FC v Chattanooga Red Wolves | W | 1-0 |
| USA USL Championship | 2022/04/02 23:30 | Birmingham Legion FC v Louisville City FC | D | 0-0 |