| Guatemala Reserve League | 2022/04/30 21:00 | CSD Municipal Reserves v Deportivo Iztapa Reserves | W | 3-4 |
| Guatemala Reserve League | 2022/04/24 21:00 | Deportivo Iztapa Reserves v Antigua GFC Reserves | W | 5-2 |
| Guatemala Reserve League | 2022/04/20 20:00 | Deportivo Iztapa Reserves v Coban Imperial Reserves | D | 2-2 |
| Guatemala Reserve League | 2022/04/17 18:00 | Nueva Concepcion Reserves v Deportivo Iztapa Reserves | W | 0-3 |
| Guatemala Reserve League | 2022/04/02 17:00 | Malacateco Reserves v Deportivo Iztapa Reserves | W | 0-2 |
| Guatemala Reserve League | 2022/03/26 17:14 | Deportivo Iztapa Reserves v CSD Comunicaciones Reserves | D | 1-1 |
| Guatemala Reserve League | 2022/02/09 18:00 | Deportivo Iztapa Reserves v Nueva Concepcion Reserves | W | 6-3 |
| Guatemala Reserve League | 2022/02/05 21:00 | Xelaju Reserves v Deportivo Iztapa Reserves | W | 1-6 |
| Guatemala Reserve League | 2022/04/20 17:00 | CD Achuapa Reserves v Xelaju Reserves | D | 1-1 |
| Guatemala Reserve League | 2022/04/16 19:00 | Malacateco Reserves v CD Achuapa Reserves | L | 1-0 |
| Guatemala Reserve League | 2022/04/10 21:00 | CD Achuapa Reserves v CSD Comunicaciones Reserves | L | 0-2 |
| Guatemala Reserve League | 2022/04/03 20:30 | Solola FC Reserves v CD Achuapa Reserves | W | 0-3 |
| Guatemala Reserve League | 2022/03/27 21:00 | CD Achuapa Reserves v Guastatoya Reserves | L | 1-2 |
| Guatemala Reserve League | 2022/02/09 18:00 | CD Achuapa Reserves v Malacateco Reserves | W | 2-1 |
| Guatemala Reserve League | 2022/02/02 21:00 | CD Achuapa Reserves v CSD Solola Reserves | W | 3-0 |
| Guatemala Reserve League | 2022/01/30 17:00 | Guastatoya Reserves v CD Achuapa Reserves | W | 0-1 |