| Uruguay Reserve League | 2022/05/02 18:00 | Defensor Sporting Reserves v Atletico Fenix Reserves | L | 0-2 |
| Uruguay Reserve League | 2022/04/05 19:00 | Defensor Sporting Reserves v Atletico River Plate Reserves | L | 0-2 |
| Uruguay Reserve League | 2022/03/29 19:00 | Boston River Reserves v Defensor Sporting Reserves | D | 1-1 |
| Uruguay Reserve League | 2022/03/22 18:00 | Defensor Sporting Reserves v Plaza Colonia Reserves | W | 3-0 |
| Uruguay Reserve League | 2022/03/15 19:30 | Montevideo Wanderers Reserves v Defensor Sporting Reserves | L | 3-1 |
| Uruguay Reserve League | 2022/03/01 19:30 | Defensor Sporting Reserves v Torque Reserves | L | 2-3 |
| Uruguay Reserve League | 2022/02/14 19:30 | Defensor Sporting Reserves v Liverpool Montevideo Reserves | L | 1-2 |
| Uruguay Reserve League | 2021/12/07 19:00 | Defensor Sporting Reserves v Juventud De Las Piedras Reserves | L | 0-1 |
| Uruguay Reserve League | 2022/05/03 13:00 | Penarol Reserves v Cerrito Reserves | L | 1-0 |
| Uruguay Reserve League | 2022/04/18 18:30 | Atletico Fenix Reserves v Cerrito Reserves | L | 3-2 |
| Uruguay Reserve League | 2022/04/05 19:00 | Cerrito Reserves v Liverpool Montevideo Reserves | D | 0-0 |
| Uruguay Reserve League | 2022/03/21 19:00 | Cerrito Reserves v Rentistas Reserves | D | 2-2 |
| Uruguay Reserve League | 2022/03/15 13:30 | Atletico River Plate Reserves v Cerrito Reserves | L | 3-0 |
| Uruguay Reserve League | 2022/03/01 19:30 | Cerrito Reserves v Deportivo Maldonado Reserves | W | 2-1 |
| Uruguay Reserve League | 2022/02/22 19:30 | Boston River Reserves v Cerrito Reserves | W | 1-2 |
| Uruguay Reserve League | 2022/02/15 19:30 | Cerrito Reserves v Danubio Reserves | L | 1-3 |