[57] Louisville 7-31 Syracuse [57] 2022-09-04 00:00
Stadium: JMA Wireless Dome Round: 1
Home Manager: Dino Babers Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2020/11/21 00:00 | Syracuse v Louisville | W | 0-30 |
| NCAAF | 2019/11/23 21:00 | Syracuse v Louisville | W | 34-56 |
| NCAAF | 2018/11/10 00:00 | Louisville v Syracuse | L | 23-54 |
| NCAAF | 2017/11/18 20:30 | Syracuse v Louisville | W | 10-56 |
| NCAAF | 2016/09/10 00:00 | Louisville v Syracuse | W | 62-28 |
| NCAAF | 2015/11/07 17:30 | Louisville v Syracuse | W | 41-17 |
| NCAAF | 2014/10/03 23:00 | Syracuse v Louisville | W | 6-28 |
Home History
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2021/10/30 23:30 | Louisville v NC State | L | 13-28 |
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2021/10/09 19:00 | Virginia v Louisville | L | 34-33 |
Away History
| NCAAF | 2021/11/28 00:30 | Pittsburgh v Syracuse | L | 31-14 |
| NCAAF | 2021/11/20 21:00 | Syracuse v NC State | L | 17-41 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | L | 3-41 |
| NCAAF | 2021/10/30 19:30 | Boston College v Syracuse | W | 6-21 |
| NCAAF | 2021/10/23 16:30 | Syracuse v Virginia Tech | W | 41-36 |
| NCAAF | 2021/10/15 23:00 | Clemson v Syracuse | L | 17-14 |
| NCAAF | 2021/10/09 19:30 | Wake Forest v Syracuse | L | 40-37 |
| NCAAF | 2021/10/02 19:30 | Syracuse v Florida State | L | 30-33 |