[11] Guayaquil City 2-2 LDU Quito [4] 2022-05-22 01:00
Stadium: Estadio Christian Benitez Betancourt Round: 14
Referee: Augusto Bergelio Aragon Bautista Home Manager: Pool Gavilanez Away Manager: Luis Zubeldia
Head to Head
| Ecuador LigaPro Serie A | 2021/10/03 01:00 | LDU Quito v Guayaquil City | L | 3-1 |
| Ecuador LigaPro Serie A | 2021/04/18 01:00 | Guayaquil City v LDU Quito | D | 2-2 |
| Ecuador LigaPro Serie A | 2020/11/22 01:00 | Guayaquil City v LDU Quito | D | 1-1 |
| Ecuador LigaPro Serie A | 2020/09/12 00:00 | LDU Quito v Guayaquil City | L | 2-0 |
| Ecuador LigaPro Serie A | 2019/07/27 00:15 | Guayaquil City v LDU Quito | W | 1-0 |
| Ecuador LigaPro Serie A | 2019/03/02 22:30 | LDU Quito v Guayaquil City | L | 4-0 |
| Ecuador LigaPro Serie A | 2018/11/06 00:15 | LDU Quito v Guayaquil City | L | 4-1 |
| Ecuador LigaPro Serie A | 2018/08/25 21:00 | Guayaquil City v LDU Quito | L | 1-4 |
Home History
| Ecuador LigaPro Serie A | 2022/05/17 00:00 | Gualaceo SC v Guayaquil City | L | 2-1 |
| Ecuador LigaPro Serie A | 2022/05/11 22:00 | Club 9 de Octubre v Guayaquil City | D | 2-2 |
| Ecuador LigaPro Serie A | 2022/05/09 00:00 | Guayaquil City v Barcelona Guayaquil | L | 1-4 |
| Ecuador LigaPro Serie A | 2022/04/30 20:00 | Mushuc Runa v Guayaquil City | L | 2-0 |
| Ecuador LigaPro Serie A | 2022/04/26 00:00 | Guayaquil City v Cumbaya FC | W | 4-1 |
| Ecuador LigaPro Serie A | 2022/04/16 22:30 | Guayaquil City v SD Aucas | W | 4-0 |
| Ecuador LigaPro Serie A | 2022/04/10 18:00 | Independiente del Valle v Guayaquil City | D | 0-0 |
| Ecuador LigaPro Serie A | 2022/04/03 21:30 | Guayaquil City v Tecnico Universitario | L | 0-1 |
Away History
| Copa Sudamericana | 2022/05/19 00:30 | LDU Quito v Defensa y Justicia | D | 2-2 |
| Ecuador LigaPro Serie A | 2022/05/15 00:00 | LDU Quito v Delfin SC | W | 3-2 |
| Ecuador LigaPro Serie A | 2022/05/08 21:30 | LDU Quito v Club 9 de Octubre | W | 2-0 |
| Copa Sudamericana | 2022/05/04 22:15 | CD Antofagasta v LDU Quito | W | 1-2 |
| Ecuador LigaPro Serie A | 2022/05/02 00:00 | Independiente del Valle v LDU Quito | L | 1-0 |
| Copa Sudamericana | 2022/04/28 22:15 | Defensa y Justicia v LDU Quito | W | 1-2 |
| Ecuador LigaPro Serie A | 2022/04/24 19:30 | LDU Quito v Mushuc Runa | W | 3-2 |
| Ecuador LigaPro Serie A | 2022/04/20 20:00 | Orense v LDU Quito | L | 3-0 |