Head to Head
| NFL | 2021/11/21 18:00 | IND Colts v BUF Bills | W | 41-15 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | L | 24-27 |
| NFL Preseason | 2019/08/08 23:00 | IND Colts v BUF Bills | L | 16-24 |
| NFL | 2018/10/21 17:00 | BUF Bills v IND Colts | W | 5-37 |
| NFL | 2017/12/10 18:00 | IND Colts v BUF Bills | L | 7-13 |
| NFL Preseason | 2016/08/13 23:00 | BUF Bills v IND Colts | W | 18-19 |
| NFL | 2015/09/13 17:00 | BUF Bills v IND Colts | L | 27-14 |
Home History
| NFL | 2022/01/09 18:00 | IND Colts v JAX Jaguars | L | 11-26 |
| NFL | 2022/01/02 18:00 | LV Raiders v IND Colts | L | 23-20 |
| NFL | 2021/12/26 01:15 | IND Colts v ARZ Cardinals | W | 22-16 |
| NFL | 2021/12/19 01:15 | NE Patriots v IND Colts | W | 17-27 |
| NFL | 2021/12/05 18:00 | IND Colts v HOU Texans | W | 31-0 |
| NFL | 2021/11/28 18:00 | TB Buccaneers v IND Colts | L | 38-31 |
| NFL | 2021/11/21 18:00 | IND Colts v BUF Bills | W | 41-15 |
| NFL | 2021/11/14 18:00 | JAX Jaguars v IND Colts | W | 17-23 |
Away History
| NFL | 2022/01/23 23:30 | BUF Bills v KC Chiefs | L | 36-42 |
| NFL | 2022/01/16 01:15 | NE Patriots v BUF Bills | W | 17-47 |
| NFL | 2022/01/09 21:25 | NY Jets v BUF Bills | W | 10-27 |
| NFL | 2022/01/02 18:00 | ATL Falcons v BUF Bills | W | 15-29 |
| NFL | 2021/12/26 18:00 | BUF Bills v NE Patriots | W | 33-21 |
| NFL | 2021/12/19 18:00 | CAR Panthers v BUF Bills | W | 14-31 |
| NFL | 2021/12/12 21:25 | BUF Bills v TB Buccaneers | L | 27-33 |
| NFL | 2021/12/07 01:15 | NE Patriots v BUF Bills | L | 14-10 |