Head to Head
| NFL Preseason | 2021/08/27 23:00 | IND Colts v DET Lions | L | 27-17 |
| NFL | 2020/11/01 18:00 | IND Colts v DET Lions | L | 41-21 |
| NFL Preseason | 2017/08/13 17:30 | DET Lions v IND Colts | W | 24-10 |
| NFL | 2016/09/11 20:25 | DET Lions v IND Colts | W | 39-35 |
Home History
| NFL Preseason | 2022/08/12 22:00 | ATL Falcons v DET Lions | L | 27-23 |
| NFL | 2022/01/09 18:00 | GB Packers v DET Lions | W | 30-37 |
| NFL | 2022/01/02 21:25 | DET Lions v SEA Seahawks | L | 29-51 |
| NFL | 2021/12/26 18:00 | DET Lions v ATL Falcons | L | 16-20 |
| NFL | 2021/12/19 18:00 | ARZ Cardinals v DET Lions | W | 12-30 |
| NFL | 2021/12/12 21:05 | DET Lions v DEN Broncos | L | 10-38 |
| NFL | 2021/12/05 18:00 | MIN Vikings v DET Lions | W | 27-29 |
| NFL | 2021/11/25 17:30 | CHI Bears v DET Lions | L | 16-14 |
Away History
| NFL Preseason | 2022/08/13 20:00 | IND Colts v BUF Bills | L | 24-27 |
| NFL | 2022/01/09 18:00 | IND Colts v JAX Jaguars | L | 11-26 |
| NFL | 2022/01/02 18:00 | LV Raiders v IND Colts | L | 23-20 |
| NFL | 2021/12/26 01:15 | IND Colts v ARZ Cardinals | W | 22-16 |
| NFL | 2021/12/19 01:15 | NE Patriots v IND Colts | W | 17-27 |
| NFL | 2021/12/05 18:00 | IND Colts v HOU Texans | W | 31-0 |
| NFL | 2021/11/28 18:00 | TB Buccaneers v IND Colts | L | 38-31 |
| NFL | 2021/11/21 18:00 | IND Colts v BUF Bills | W | 41-15 |