| Colombia Regional League | 2022/05/16 14:19 | Lula FC v Medellin City FC | L | 1-0 |
| Colombia Regional League | 2022/05/05 15:00 | Medellin City FC v Aguilas Doradas Reserves | W | 4-2 |
| Colombia Regional League | 2022/04/11 17:00 | Sellos Colombianos v Medellin City FC | L | 4-3 |
| Colombia Regional League | 2022/03/28 16:15 | Ferrovalvulas FC v Medellin City FC | L | 2-1 |
| Colombia Regional League | 2022/03/18 14:10 | Medellin City FC v Politecnico J.I.C. | D | 0-0 |
| Colombia Regional League | 2022/05/09 14:00 | Lula FC v Estudiantes de Medellin | W | 2-3 |
| Colombia Regional League | 2022/04/11 16:00 | Estudiantes de Medellin v Real Santuario | D | 1-1 |
| Colombia Regional League | 2022/04/04 15:10 | Club Deportivo La Chalaca v Estudiantes de Medellin | L | 3-1 |
| Colombia Regional League | 2022/02/28 16:00 | Sellos Colombianos v Estudiantes de Medellin | L | 6-3 |
| Colombia Regional League | 2021/11/27 21:30 | CFD La Nororiental v Estudiantes de Medellin | D | 0-0 |
| Colombia Regional League | 2021/11/16 17:00 | Estudiantes de Medellin v Molino Viejo | L | 1-2 |
| Colombia Regional League | 2021/11/14 21:12 | Estudiantes de Medellin v CD Gallegol | W | 1-0 |
| Colombia Regional League | 2021/10/18 17:00 | Estudiantes de Medellin v Politecnico J.I.C. | W | 2-1 |