[5] South Florida 28-31 Florida [13] 2022-09-17 23:30
Stadium: Ben Hill Griffin Stadium Round: 1
Home Manager: Billy Napier Away Manager: Jeff Scott
Head to Head
| NCAAF | 2021/09/11 17:00 | Florida v South Florida | L | 42-20 |
| NCAAF | 2010/09/11 12:00 | Florida v South Florida | L | 38-14 |
Home History
| NCAAF | 2022/09/10 23:00 | Howard v South Florida | W | 20-42 |
| NCAAF | 2022/09/03 20:00 | BYU v South Florida | L | 50-21 |
| NCAAF | 2021/11/26 20:30 | South Florida v Central Florida | L | 13-17 |
| NCAAF | 2021/11/20 17:00 | South Florida v Tulane | L | 14-45 |
| NCAAF | 2021/11/12 23:00 | Cincinnati v South Florida | L | 45-28 |
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | L | 54-42 |
| NCAAF | 2021/10/28 23:30 | South Florida v East Carolina | L | 14-29 |
| NCAAF | 2021/10/23 23:00 | Temple v South Florida | W | 14-34 |
Away History
| NCAAF | 2022/09/10 23:00 | Kentucky v Florida | L | 26-16 |
| NCAAF | 2022/09/03 23:00 | Utah v Florida | W | 26-29 |
| NCAAF Bowl Games | 2021/12/24 00:00 | Central Florida v Florida | L | 29-17 |
| NCAAF | 2021/11/27 17:00 | Florida State v Florida | W | 21-24 |
| NCAAF | 2021/11/20 21:00 | Florida v Missouri | L | 23-24 |
| NCAAF | 2021/11/13 17:00 | Samford v Florida | W | 52-70 |
| NCAAF | 2021/11/06 23:30 | Florida v South Carolina | L | 17-40 |
| NCAAF | 2021/10/30 19:30 | Georgia v Florida | L | 34-7 |