[7] Louisiana Tech 20-48 Clemson [1] 2022-09-18 00:00
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Sonny Cumbie
Head to Head
| NCAAF | 2006/09/30 12:00 | Clemson v Louisiana Tech | L | 51-0 |
| NCAAF | 2002/09/07 12:00 | Clemson v Louisiana Tech | L | 33-13 |
| NCAAF Bowl Games | 2001/12/31 12:00 | Clemson v Louisiana Tech | L | 49-24 |
Home History
| NCAAF | 2022/09/10 23:00 | Stephen F. Austin v Louisiana Tech | W | 17-52 |
| NCAAF | 2022/09/02 00:00 | Louisiana Tech v Missouri | L | 24-52 |
| NCAAF | 2021/11/27 18:00 | Louisiana Tech v Rice | L | 31-35 |
| NCAAF | 2021/11/20 01:00 | Southern Mississippi v Louisiana Tech | L | 35-19 |
| NCAAF | 2021/11/13 20:30 | Charlotte v Louisiana Tech | W | 32-42 |
| NCAAF | 2021/11/06 16:00 | Louisiana Tech v UAB | L | 38-52 |
| NCAAF | 2021/10/30 19:30 | Louisiana Tech v Old Dominion | L | 20-23 |
| NCAAF | 2021/10/23 23:00 | Texas-San Antonio v Louisiana Tech | L | 45-16 |
Away History
| NCAAF | 2022/09/10 19:30 | Furman v Clemson | W | 12-35 |
| NCAAF | 2022/09/06 00:00 | Clemson v Georgia Tech | W | 41-10 |
| NCAAF Bowl Games | 2021/12/29 22:45 | Iowa State v Clemson | W | 13-20 |
| NCAAF | 2021/11/28 00:30 | Clemson v South Carolina | W | 30-0 |
| NCAAF | 2021/11/20 17:00 | Wake Forest v Clemson | W | 27-48 |
| NCAAF | 2021/11/13 17:00 | Connecticut v Clemson | W | 7-44 |
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | W | 30-24 |
| NCAAF | 2021/10/30 19:30 | Florida State v Clemson | W | 20-30 |