[12] South Dakota State 3-7 Iowa [4] 2022-09-03 16:00
Stadium: Kinnick Stadium Round: 1
Home Manager: Kirk Ferentz Away Manager: John Stiegelmeier
Home History
| NCAAF | 2021/12/18 19:00 | South Dakota State v Montana State | L | 17-31 |
| NCAAF | 2021/12/11 19:00 | South Dakota State v Villanova | W | 35-21 |
| NCAAF | 2021/12/05 02:00 | South Dakota State v CS Sacramento | W | 24-19 |
| NCAAF | 2021/11/27 20:00 | UC Davis v South Dakota State | W | 24-56 |
| NCAAF | 2021/11/20 20:00 | North Dakota v South Dakota State | W | 21-24 |
| NCAAF | 2021/11/13 19:00 | South Dakota State v South Dakota | L | 20-23 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | W | 19-27 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | W | 47-16 |
Away History
| NCAAF Bowl Games | 2022/01/01 18:00 | Kentucky v Iowa | L | 20-17 |
| NCAAF | 2021/12/05 01:00 | Iowa v Michigan | L | 3-42 |
| NCAAF | 2021/11/26 18:30 | Iowa v Nebraska | W | 28-21 |
| NCAAF | 2021/11/20 19:00 | Illinois v Iowa | W | 23-33 |
| NCAAF | 2021/11/13 20:30 | Minnesota v Iowa | W | 22-27 |
| NCAAF | 2021/11/06 23:00 | Iowa v Northwestern | W | 17-12 |
| NCAAF | 2021/10/30 16:00 | Iowa v Wisconsin | L | 7-27 |
| NCAAF | 2021/10/16 19:30 | Purdue v Iowa | L | 24-7 |