[70] Houston 30-33 Texas Tech [17] 2022-09-10 20:00
Stadium: Jones AT&T Stadium Round: 1
Home Manager: Joey McGuire Away Manager: Dana Holgorsen
Head to Head
| NCAAF | 2021/09/04 23:00 | Texas Tech v Houston | L | 38-21 |
| NCAAF | 2018/09/15 20:15 | Houston v Texas Tech | L | 49-63 |
| NCAAF | 2017/09/23 16:00 | Texas Tech v Houston | L | 27-24 |
| NCAAF | 2010/11/27 12:00 | Texas Tech v Houston | L | 35-20 |
| NCAAF | 2009/09/26 12:00 | Houston v Texas Tech | W | 29-28 |
Home History
| NCAAF | 2022/09/03 19:30 | Houston v Texas-San Antonio | W | 37-35 |
| NCAAF Bowl Games | 2021/12/28 17:00 | Houston v Auburn | W | 17-13 |
| NCAAF | 2021/12/04 21:00 | Houston v Cincinnati | L | 20-35 |
| NCAAF | 2021/11/27 17:00 | Houston v Connecticut | W | 45-17 |
| NCAAF | 2021/11/20 02:00 | Memphis v Houston | W | 13-31 |
| NCAAF | 2021/11/13 17:00 | Houston v Temple | W | 37-8 |
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | W | 54-42 |
| NCAAF | 2021/10/30 23:00 | SMU v Houston | W | 37-44 |
Away History
| NCAAF | 2022/09/04 00:00 | Murray State v Texas Tech | W | 10-63 |
| NCAAF Bowl Games | 2021/12/28 23:45 | Texas Tech v Mississippi State | W | 34-7 |
| NCAAF | 2021/11/27 17:00 | Texas Tech v Baylor | L | 24-27 |
| NCAAF | 2021/11/21 01:00 | Oklahoma State v Texas Tech | L | 23-0 |
| NCAAF | 2021/11/13 20:30 | Iowa State v Texas Tech | W | 38-41 |
| NCAAF | 2021/10/30 19:30 | Texas Tech v Oklahoma | L | 21-52 |
| NCAAF | 2021/10/23 16:00 | Kansas State v Texas Tech | L | 25-24 |
| NCAAF | 2021/10/16 20:00 | Texas Tech v Kansas | W | 41-14 |