[3] Eastern Illinois 27-34 Northern Illinois [57] 2022-09-02 00:00
Stadium: Brigham Field at Huskie Stadium Round: 1
Home Manager: Thomas Hammock Away Manager: Chris Wilkerson
Home History
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | L | 20-13 |
| NCAAF | 2021/11/06 19:00 | Eastern Illinois v Austin Peay | L | 26-42 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | L | 15-38 |
| NCAAF | 2021/10/23 19:00 | Tennessee State v Eastern Illinois | L | 28-0 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | L | 28-17 |
| NCAAF | 2021/10/02 21:00 | Eastern Illinois v Murray State | L | 6-22 |
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | W | 28-14 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | L | 31-24 |
Away History
| NCAAF Bowl Games | 2021/12/17 23:00 | Coastal Carolina v Northern Illinois | L | 47-41 |
| NCAAF | 2021/12/04 17:00 | Kent State v Northern Illinois | W | 23-41 |
| NCAAF | 2021/11/24 00:00 | Western Michigan v Northern Illinois | L | 42-21 |
| NCAAF | 2021/11/18 00:00 | Northern Illinois v Buffalo | W | 33-27 |
| NCAAF | 2021/11/11 00:00 | Ball State v Northern Illinois | W | 29-30 |
| NCAAF | 2021/11/03 23:00 | Northern Illinois v Kent State | L | 47-52 |
| NCAAF | 2021/10/23 16:00 | Northern Illinois v Central Michigan | W | 39-38 |
| NCAAF | 2021/10/16 19:30 | Bowling Green v Northern Illinois | W | 26-34 |