[12] Eastern Kentucky 34-42 Eastern Michigan [28] 2022-09-02 23:00
Stadium: Rynearson Stadium Round: 1
Home Manager: Chris Creighton Away Manager: Walt Wells
Home History
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | W | 31-39 |
| NCAAF | 2021/11/13 18:00 | Eastern Kentucky v Sam Houston State | L | 28-42 |
| NCAAF | 2021/11/06 21:00 | Eastern Kentucky v Stephen F. Austin | L | 17-31 |
| NCAAF | 2021/10/30 18:00 | Lamar v Eastern Kentucky | W | 10-42 |
| NCAAF | 2021/10/16 21:00 | Eastern Kentucky v Central Arkansas | W | 38-35 |
| NCAAF | 2021/10/09 22:00 | Abilene Christian v Eastern Kentucky | W | 15-30 |
| NCAAF | 2021/10/02 19:00 | Tarleton State v Eastern Kentucky | W | 3-20 |
| NCAAF | 2021/09/25 19:00 | Austin Peay v Eastern Kentucky | W | 27-35 |
Away History
| NCAAF Bowl Games | 2021/12/18 22:45 | Eastern Michigan v Liberty | L | 20-56 |
| NCAAF | 2021/11/26 17:00 | Eastern Michigan v Central Michigan | L | 10-31 |
| NCAAF | 2021/11/17 00:30 | Western Michigan v Eastern Michigan | W | 21-22 |
| NCAAF | 2021/11/10 01:00 | Ohio v Eastern Michigan | L | 34-26 |
| NCAAF | 2021/11/02 23:30 | Eastern Michigan v Toledo | W | 52-49 |
| NCAAF | 2021/10/23 16:00 | Eastern Michigan v Bowling Green | W | 55-24 |
| NCAAF | 2021/10/16 18:00 | Ball State v Eastern Michigan | L | 38-31 |
| NCAAF | 2021/10/09 19:30 | Miami Ohio v Eastern Michigan | W | 12-13 |