[12] SE Missouri State 10-42 Iowa State [41] 2022-09-03 18:00
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Tom Matukewicz
Home History
| NCAAF | 2021/11/20 19:00 | Tennessee Martin v SE Missouri St | W | 14-31 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | L | 10-28 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | L | 30-38 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/10/09 20:00 | SE Missouri St v Austin Peay | W | 30-14 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | L | 17-28 |
| NCAAF | 2021/09/25 19:00 | Tennessee State v SE Missouri St | W | 14-47 |
Away History
| NCAAF Bowl Games | 2021/12/29 22:45 | Iowa State v Clemson | L | 13-20 |
| NCAAF | 2021/11/26 21:30 | TCU v Iowa State | W | 14-48 |
| NCAAF | 2021/11/20 17:00 | Iowa State v Oklahoma | L | 21-28 |
| NCAAF | 2021/11/13 20:30 | Iowa State v Texas Tech | L | 38-41 |
| NCAAF | 2021/11/06 23:30 | Texas v Iowa State | W | 7-30 |
| NCAAF | 2021/10/30 18:00 | Iowa State v West Virginia | L | 31-38 |
| NCAAF | 2021/10/23 19:30 | Oklahoma State v Iowa State | W | 21-24 |
| NCAAF | 2021/10/16 23:30 | Iowa State v Kansas State | W | 33-20 |