[14] Guayaquil City 4-1 Mushuc Runa [13] 2022-09-20 00:00
Stadium: Estadio Christian Benitez Betancourt Round: 11
Referee: Alex Fabricio Cajas Torres Home Manager: Pool Gavilanez Away Manager: Geovanny Cumbicus
Head to Head
| Ecuador LigaPro Serie A | 2022/04/30 20:00 | Mushuc Runa v Guayaquil City | L | 2-0 |
| Ecuador LigaPro Serie A | 2021/11/21 20:30 | Mushuc Runa v Guayaquil City | L | 1-0 |
| Ecuador LigaPro Serie A | 2021/05/29 21:30 | Guayaquil City v Mushuc Runa | D | 0-0 |
| Ecuador LigaPro Serie A | 2020/11/14 18:00 | Guayaquil City v Mushuc Runa | W | 3-2 |
| Ecuador LigaPro Serie A | 2020/09/26 19:45 | Mushuc Runa v Guayaquil City | L | 2-1 |
| Ecuador LigaPro Serie A | 2019/08/25 19:45 | Guayaquil City v Mushuc Runa | W | 4-2 |
| Ecuador LigaPro Serie A | 2019/04/06 20:00 | Mushuc Runa v Guayaquil City | L | 3-2 |
| Ecuador LigaPro Serie A | 2016/10/30 17:00 | Mushuc Runa v Guayaquil City | W | 0-2 |
Home History
| Ecuador LigaPro Serie A | 2022/09/10 21:30 | Cumbaya FC v Guayaquil City | L | 3-0 |
| Ecuador LigaPro Serie A | 2022/09/03 21:30 | Guayaquil City v Club 9 de Octubre | D | 1-1 |
| Ecuador LigaPro Serie A | 2022/08/27 22:30 | SD Aucas v Guayaquil City | L | 2-1 |
| Ecuador LigaPro Serie A | 2022/08/23 00:00 | Guayaquil City v Independiente del Valle | L | 0-1 |
| Ecuador LigaPro Serie A | 2022/08/14 20:30 | Tecnico Universitario v Guayaquil City | L | 3-1 |
| Ecuador LigaPro Serie A | 2022/08/06 22:30 | Guayaquil City v Macara | D | 0-0 |
| Ecuador LigaPro Serie A | 2022/07/30 20:00 | Delfin SC v Guayaquil City | W | 1-3 |
| Ecuador LigaPro Serie A | 2022/07/24 01:00 | Guayaquil City v Emelec | D | 0-0 |
Away History
| Ecuador Cup | 2022/09/16 23:00 | El Nacional v Mushuc Runa | L | 1-0 |
| Ecuador LigaPro Serie A | 2022/09/10 00:00 | Mushuc Runa v LDU Quito | L | 1-2 |
| Ecuador LigaPro Serie A | 2022/09/04 19:00 | Macara v Mushuc Runa | L | 3-0 |
| Ecuador LigaPro Serie A | 2022/08/28 19:00 | Mushuc Runa v Gualaceo SC | W | 2-0 |
| Ecuador Cup | 2022/08/25 22:00 | Mushuc Runa v Independiente del Valle | L | 2-4 |
| Ecuador Cup | 2022/08/18 00:00 | Club 9 de Octubre v Mushuc Runa | L | 2-0 |
| Ecuador LigaPro Serie A | 2022/08/13 00:00 | Mushuc Runa v Orense | D | 1-1 |
| Ecuador LigaPro Serie A | 2022/08/08 00:00 | Barcelona Guayaquil v Mushuc Runa | L | 4-1 |