[4] Santos Laguna 3-0 Mazatlan FC [14] 2022-10-02 23:05
Stadium: Estadio TSM Corona Round: 17
Referee: Adonai Escobedo Gonzalez Home Manager: Eduardo Fentanes Away Manager: Gabriel Caballero
Head to Head
| Mexico Liga MX | 2022/04/20 02:00 | Mazatlan FC v Santos Laguna | L | 1-0 |
| Club Friendly List | 2022/01/29 02:00 | Mazatlan FC v Santos Laguna | L | 2-1 |
| Mexico Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlan FC | W | 1-0 |
| Mexico Liga MX | 2021/01/23 03:30 | Mazatlan FC v Santos Laguna | D | 0-0 |
| Mexico Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlan FC | W | 4-0 |
| Mexico Liga MX | 2016/07/31 23:00 | Santos Laguna v Mazatlan FC | L | 2-4 |
| Mexico Liga MX | 2016/05/01 01:30 | Mazatlan FC v Santos Laguna | L | 3-2 |
| Mexico Liga MX | 2015/11/07 03:30 | Santos Laguna v Mazatlan FC | L | 2-3 |
Home History
| Mexico Liga MX | 2022/09/19 00:05 | Santos Laguna v Juarez FC | W | 2-0 |
| Mexico Liga MX | 2022/09/15 02:05 | Club America v Santos Laguna | D | 3-3 |
| Mexico Liga MX | 2022/09/10 22:00 | Queretaro v Santos Laguna | D | 3-3 |
| Mexico Liga MX | 2022/09/07 00:05 | Santos Laguna v Necaxa | W | 3-1 |
| Mexico Liga MX | 2022/09/03 22:05 | Pachuca v Santos Laguna | L | 2-0 |
| Mexico Liga MX | 2022/08/29 00:05 | Santos Laguna v Atletico San Luis | W | 4-1 |
| Mexico Liga MX | 2022/08/26 02:05 | Tijuana v Santos Laguna | W | 0-2 |
| Mexico Liga MX | 2022/08/21 17:00 | Unam Pumas v Santos Laguna | W | 1-5 |
Away History
| Mexico Liga MX | 2022/09/24 00:00 | Necaxa v Mazatlan FC | D | 2-2 |
| Mexico Liga MX | 2022/09/17 02:00 | Mazatlan FC v Toluca | D | 1-1 |
| Mexico Liga MX | 2022/09/11 21:00 | Cruz Azul v Mazatlan FC | L | 2-0 |
| Mexico Liga MX | 2022/09/08 02:05 | Mazatlan FC v Atlas | W | 1-0 |
| Mexico Liga MX | 2022/09/04 00:05 | Monterrey v Mazatlan FC | D | 0-0 |
| Mexico Liga MX | 2022/08/27 02:05 | Mazatlan FC v Club America | L | 1-3 |
| Mexico Liga MX | 2022/08/21 02:05 | Juarez FC v Mazatlan FC | D | 1-1 |
| Mexico Liga MX | 2022/08/17 00:00 | Mazatlan FC v Queretaro | D | 1-1 |