[4] Western Kentucky 35-17 Middle Tennessee [8] 2022-10-15 19:30
Stadium: Johnny "Red" Floyd Stadium Round: 1
Home Manager: Rick Stockstill Away Manager: Tyson Helton
Head to Head
| NCAAF | 2021/11/06 19:30 | Middle Tennessee St. v Western Kentucky | W | 21-48 |
| NCAAF | 2020/10/03 21:00 | Western Kentucky v Middle Tennessee St. | W | 20-17 |
| NCAAF | 2019/11/30 19:00 | Middle Tennessee St. v Western Kentucky | W | 26-31 |
| NCAAF | 2018/11/03 00:00 | Western Kentucky v Middle Tennessee St. | L | 10-29 |
| NCAAF | 2017/11/18 01:00 | Middle Tennessee St. v Western Kentucky | W | 38-41 |
| NCAAF | 2016/10/15 18:30 | Western Kentucky v Middle Tennessee St. | W | 44-43 |
| NCAAF | 2015/10/10 16:00 | Western Kentucky v Middle Tennessee St. | W | 58-28 |
| NCAAF | 2014/09/13 23:00 | Middle Tennessee St. v Western Kentucky | L | 50-47 |
Home History
| NCAAF | 2022/10/08 22:00 | Western Kentucky v Texas-San Antonio | L | 28-31 |
| NCAAF | 2022/10/01 23:00 | Troy v Western Kentucky | L | 34-27 |
| NCAAF | 2022/09/24 19:30 | Florida Intl v Western Kentucky | W | 0-73 |
| NCAAF | 2022/09/17 16:00 | Western Kentucky v Indiana | L | 30-33 |
| NCAAF | 2022/09/04 04:00 | Western Kentucky v Hawaii | W | 49-17 |
| NCAAF | 2022/08/27 16:00 | Austin Peay v Western Kentucky | W | 27-38 |
| NCAAF Bowl Games | 2021/12/18 16:00 | Appalachian St v Western Kentucky | W | 38-59 |
| NCAAF | 2021/12/04 00:00 | Western Kentucky v Texas-San Antonio | L | 41-49 |
Away History
| NCAAF | 2022/10/08 19:30 | Middle Tennessee St. v UAB | L | 14-41 |
| NCAAF | 2022/09/30 23:30 | Texas-San Antonio v Middle Tennessee St. | L | 45-30 |
| NCAAF | 2022/09/24 19:30 | Middle Tennessee St. v Miami Florida | W | 45-31 |
| NCAAF | 2022/09/17 23:00 | Tennessee State v Middle Tennessee St. | W | 6-49 |
| NCAAF | 2022/09/10 20:00 | Middle Tennessee St. v Colorado State | W | 34-19 |
| NCAAF | 2022/09/03 22:00 | Middle Tennessee St. v James Madison | L | 7-44 |
| NCAAF Bowl Games | 2021/12/17 17:00 | Toledo v Middle Tennessee St. | W | 24-31 |
| NCAAF | 2021/11/28 00:00 | Middle Tennessee St. v Florida Atlantic | W | 27-17 |