[18] Reilly Opelka 4-6,4-6 Alex De Minaur [21] 2022-06-13 11:00
Stadium: Centre Court Round: 25 Ground: Grass
Head to Head
| ATP Basel | 2019/10/26 12:30 | Reilly Opelka v Alex De Minaur | 6-7,7-6,6-7 |
| ATP Cincinnati | 2019/08/14 15:00 | Alex De Minaur v Reilly Opelka | 7-6,6-4 |
| ATP Atlanta | 2019/07/27 19:00 | Reilly Opelka v Alex De Minaur | 6-7,7-6,3-6 |
| ATP Sydney | 2019/01/08 10:05 | Alex De Minaur v Reilly Opelka | 6-4,7-6 |
Home History
| French Open | 2022/05/23 09:00 | Filip Krajinovic v Reilly Opelka | 7-6,6-2,6-3 |
| ATP Geneva | 2022/05/20 12:15 | Reilly Opelka v Casper Ruud | 6-7,5-7 |
| ATP Geneva | 2022/05/19 11:30 | Tallon Griekspoor v Reilly Opelka | 4-6,6-3,3-6 |
| ATP Geneva | 2022/05/18 10:00 | Christopher O'Connell v Reilly Opelka | 3-6,5-7 |
| ATP Rome | 2022/05/09 09:00 | Stan Wawrinka v Reilly Opelka | 3-6,7-5,6-2 |
| ATP Madrid | 2022/05/03 18:20 | Reilly Opelka v Sebastian Korda | 3-6,5-7 |
| ATP Munich | 2022/04/28 13:30 | Reilly Opelka v Oscar Otte | 6-7,2-6 |
| ATP Houston | 2022/04/10 19:00 | Reilly Opelka v John Isner | 6-3,7-6 |
Away History
| ATP Hertogenbosch | 2022/06/09 11:55 | Alex De Minaur v Adrian Mannarino | 2-6,3-6 |
| French Open | 2022/05/24 14:05 | Hugo Gaston v Alex De Minaur | 4-6,6-2,6-3,0-6,7-6 |
| ATP Lyon | 2022/05/20 12:30 | Alex De Minaur v Alex Molcan | 6-7,2-6 |
| ATP Lyon | 2022/05/17 16:10 | Ugo Humbert v Alex De Minaur | 6-1,3-6,2-6 |
| ATP Rome | 2022/05/12 09:00 | Alex De Minaur v Alexander Zverev | 3-6,6-7 |
| ATP Rome | 2022/05/11 11:55 | Alex De Minaur v Tommy Paul | 7-5,6-4 |
| ATP Rome | 2022/05/09 18:10 | Dusan Lajovic v Alex De Minaur | 4-6,1-6 |
| ATP Madrid | 2022/05/04 18:50 | Alex De Minaur v Jannik Sinner | 4-6,1-6 |