[2] Man City 4-0 Southampton [16] 2022-10-08 14:00
Stadium: Etihad Stadium Round: 10
Referee: Andrew Madley Home Manager: Pep Guardiola Away Manager: Ralph Hasenhuttl
Head to Head
| England FA Cup | 2022/03/20 15:00 | Southampton v Man City | W | 1-4 |
| England Premier League | 2022/01/22 17:30 | Southampton v Man City | D | 1-1 |
| England Premier League | 2021/09/18 14:00 | Man City v Southampton | D | 0-0 |
| England Premier League | 2021/03/10 18:00 | Man City v Southampton | W | 5-2 |
| England Premier League | 2020/12/19 15:00 | Southampton v Man City | W | 0-1 |
| England Premier League | 2020/07/05 18:00 | Southampton v Man City | L | 1-0 |
| England Premier League | 2019/11/02 15:00 | Man City v Southampton | W | 2-1 |
| England EFL Cup | 2019/10/29 19:45 | Man City v Southampton | W | 3-1 |
Home History
| UEFA Champions League | 2022/10/05 19:00 | Man City v FC Copenhagen | W | 5-0 |
| England Premier League | 2022/10/02 13:00 | Man City v Man Utd | W | 6-3 |
| England Premier League | 2022/09/17 11:30 | Wolverhampton v Man City | W | 0-3 |
| UEFA Champions League | 2022/09/14 19:00 | Man City v Borussia Dortmund | W | 2-1 |
| UEFA Champions League | 2022/09/06 19:00 | Sevilla v Man City | W | 0-4 |
| England Premier League | 2022/09/03 16:30 | Aston Villa v Man City | D | 1-1 |
| England Premier League | 2022/08/31 18:30 | Man City v Nottm Forest | W | 6-0 |
| England Premier League | 2022/08/27 14:00 | Man City v Crystal Palace | W | 4-2 |
Away History
| England Premier League | 2022/10/01 14:00 | Southampton v Everton | L | 1-2 |
| England Premier League | 2022/09/16 19:00 | Aston Villa v Southampton | L | 1-0 |
| England Premier League | 2022/09/03 14:00 | Wolverhampton v Southampton | L | 1-0 |
| England Premier League | 2022/08/30 18:45 | Southampton v Chelsea | W | 2-1 |
| England Premier League | 2022/08/27 11:30 | Southampton v Man Utd | L | 0-1 |
| England EFL Cup | 2022/08/23 18:45 | Cambridge Utd v Southampton | W | 0-3 |
| England Premier League | 2022/08/20 14:00 | Leicester v Southampton | W | 1-2 |
| England Premier League | 2022/08/13 14:00 | Southampton v Leeds | D | 2-2 |