| Colombia Regional League | 2022/06/12 15:22 | Talento y Vida v Estudiantes de Medellin | W | 1-2 |
| Colombia Regional League | 2022/06/06 14:00 | Estudiantes de Medellin v Envigado FC Reserves | D | 0-0 |
| Colombia Regional League | 2022/05/30 19:29 | Estudiantes de Medellin v FC Leones Reserves | L | 0-2 |
| Colombia Regional League | 2022/05/24 15:00 | Medellin City FC v Estudiantes de Medellin | L | 5-2 |
| Colombia Regional League | 2022/05/09 14:00 | Lula FC v Estudiantes de Medellin | W | 2-3 |
| Colombia Regional League | 2022/04/11 16:00 | Estudiantes de Medellin v Real Santuario | D | 1-1 |
| Colombia Regional League | 2022/04/04 15:10 | Club Deportivo La Chalaca v Estudiantes de Medellin | L | 3-1 |
| Colombia Regional League | 2022/02/28 16:00 | Sellos Colombianos v Estudiantes de Medellin | L | 6-3 |
| Colombia Regional League | 2022/06/10 13:00 | Envigado FC Reserves v Atletico Nacional Medellin Reserves | L | 2-0 |
| Colombia Regional League | 2022/05/24 15:00 | FC Leones Reserves v Atletico Nacional Medellin Reserves | L | 2-1 |
| Colombia Regional League | 2022/05/10 17:13 | Universidad de Antioquia v Atletico Nacional Medellin Reserves | W | 0-1 |
| Colombia Regional League | 2022/04/23 16:00 | Independiente Sabaneta v Atletico Nacional Medellin Reserves | D | 0-0 |
| Colombia Regional League | 2022/03/22 17:14 | Talento y Vida v Atletico Nacional Medellin Reserves | W | 0-5 |
| Colombia Regional League | 2021/11/27 19:24 | Atletico Nacional Medellin Reserves v Deportivo Alexis Garcia | W | 2-0 |
| Colombia Regional League | 2021/09/04 21:14 | Aguilas Doradas Reserves v Atletico Nacional Medellin Reserves | L | 2-1 |
| Colombia Regional League | 2021/07/31 21:06 | Inder Girardota v Atletico Nacional Medellin Reserves | W | 1-2 |