| Colombia Regional League | 2022/06/16 12:19 | Molino Viejo v Medellin City FC | L | 3-1 |
| Colombia Regional League | 2022/05/27 15:00 | Club Deportivo La Chalaca v Medellin City FC | L | 4-1 |
| Colombia Regional League | 2022/05/24 15:00 | Medellin City FC v Estudiantes de Medellin | W | 5-2 |
| Colombia Regional League | 2022/05/16 14:19 | Lula FC v Medellin City FC | L | 1-0 |
| Colombia Regional League | 2022/05/05 15:00 | Medellin City FC v Aguilas Doradas Reserves | W | 4-2 |
| Colombia Regional League | 2022/04/11 17:00 | Sellos Colombianos v Medellin City FC | L | 4-3 |
| Colombia Regional League | 2022/03/28 16:15 | Ferrovalvulas FC v Medellin City FC | L | 2-1 |
| Colombia Regional League | 2022/03/18 14:10 | Medellin City FC v Politecnico J.I.C. | D | 0-0 |
| Colombia Regional League | 2022/06/20 19:34 | E.D.P IND. Medellin v Sellos Colombianos | W | 3-0 |
| Colombia Regional League | 2022/05/18 01:06 | Real San Jeronimo v E.D.P IND. Medellin | L | 2-0 |
| Colombia Regional League | 2022/05/04 16:00 | Total Soccer FC v E.D.P IND. Medellin | - | View |
| Colombia Regional League | 2022/04/27 15:11 | E.D.P IND. Medellin v Ferrovalvulas FC | D | 2-2 |
| Colombia Regional League | 2022/03/23 17:16 | E.D.P IND. Medellin v Sol de Oriente | L | 1-2 |
| Colombia Regional League | 2022/03/01 17:13 | E.D.P IND. Medellin v Real Santuario | W | 2-0 |
| Colombia Regional League | 2021/12/05 17:15 | E.D.P IND. Medellin v Ferrovalvulas FC | L | 0-2 |
| Colombia Regional League | 2021/11/12 23:10 | E.D.P IND. Medellin v Politecnico J.I.C. | W | 1-0 |