[9] Club America Women 2-0 Santos Laguna Women [7] 2022-07-20 00:00
Stadium: Estadio Azteca Round: 2
Head to Head
| Mexico Liga MX Femenil | 2022/04/12 00:00 | Santos Laguna Women v Club America Women | W | 0-3 |
| Mexico Liga MX Femenil | 2021/07/18 17:00 | Club America Women v Santos Laguna Women | W | 2-1 |
| Mexico Liga MX Femenil | 2021/04/06 00:00 | Santos Laguna Women v Club America Women | W | 1-2 |
| Mexico Liga MX Femenil | 2020/09/18 21:00 | Club America Women v Santos Laguna Women | W | 2-1 |
| Mexico Liga MX Femenil | 2020/01/20 21:45 | Club America Women v Santos Laguna Women | W | 3-2 |
| Mexico Liga MX Femenil | 2019/10/22 00:00 | Santos Laguna Women v Club America Women | W | 0-1 |
Home History
| Women’s Friendly | 2022/07/15 21:00 | Club America Women v Bayer Leverkusen Women | W | 1-0 |
| Mexico Liga MX Femenil | 2022/07/08 20:45 | Club America Women v Toluca Women | W | 2-1 |
| Mexico Liga MX Femenil | 2022/05/08 17:00 | Club America Women v Pachuca Women | L | 1-2 |
| Mexico Liga MX Femenil | 2022/05/06 00:00 | Pachuca Women v Club America Women | L | 2-1 |
| Mexico Liga MX Femenil | 2022/05/01 23:00 | Tigres UANL Women v Club America Women | D | 1-1 |
| Mexico Liga MX Femenil | 2022/04/26 00:00 | Club America Women v Pachuca Women | W | 4-0 |
| Mexico Liga MX Femenil | 2022/04/19 02:00 | Tijuana Women v Club America Women | D | 2-2 |
| Mexico Liga MX Femenil | 2022/04/12 00:00 | Santos Laguna Women v Club America Women | W | 0-3 |
Away History
| Mexico Liga MX Femenil | 2022/07/11 00:05 | Santos Laguna Women v Queretaro Women | W | 4-3 |
| Mexico Liga MX Femenil | 2022/05/03 00:00 | Santos Laguna Women v Mazatlan FC Women | W | 1-0 |
| Mexico Liga MX Femenil | 2022/04/26 00:00 | Santos Laguna Women v Juarez FC Women | W | 3-1 |
| Mexico Liga MX Femenil | 2022/04/19 00:00 | Tigres UANL Women v Santos Laguna Women | L | 4-1 |
| Mexico Liga MX Femenil | 2022/04/12 00:00 | Santos Laguna Women v Club America Women | L | 0-3 |
| Mexico Liga MX Femenil | 2022/04/01 03:00 | Santos Laguna Women v Puebla Women | D | 0-0 |
| Mexico Liga MX Femenil | 2022/03/27 16:00 | Monterrey Women v Santos Laguna Women | L | 3-1 |
| Mexico Liga MX Femenil | 2022/03/20 23:00 | Atletico San Luis Women v Santos Laguna Women | W | 2-4 |