| Colombia Regional League | 2022/06/11 17:18 | Real Santuario v Total Soccer FC | W | 3-0 |
| Colombia Regional League | 2022/06/05 21:17 | Ferrovalvulas FC v Real Santuario | L | 2-0 |
| Colombia Regional League | 2022/05/30 17:23 | Sol de Oriente v Real Santuario | L | 2-1 |
| Colombia Regional League | 2022/05/24 17:12 | Real Santuario v Politecnico J.I.C. | W | 3-0 |
| Colombia Regional League | 2022/05/10 13:15 | Real Santuario v Envigado FC Reserves | L | 1-3 |
| Colombia Regional League | 2022/04/23 17:18 | Real Santuario v FC Leones Reserves | D | 2-2 |
| Colombia Regional League | 2022/04/11 16:00 | Estudiantes de Medellin v Real Santuario | D | 1-1 |
| Colombia Regional League | 2022/03/27 13:12 | Real Santuario v Deportivo Alexis Garcia | L | 0-2 |
| Colombia Regional League | 2022/06/11 21:16 | Deportivo Alexis Garcia v Real San Jeronimo | L | 1-0 |
| Colombia Regional League | 2022/05/23 16:00 | CD Gallegol v Real San Jeronimo | L | 8-1 |
| Colombia Regional League | 2022/05/18 01:06 | Real San Jeronimo v E.D.P IND. Medellin | W | 2-0 |