[26] BUF Sabres 1-4 OTT Senators [30] 2022-11-17 00:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | W | 1-4 |
| NHL | 2022/02/18 00:00 | OTT Senators v BUF Sabres | L | 3-1 |
| NHL | 2022/01/26 00:00 | BUF Sabres v OTT Senators | L | 0-5 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | L | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | L | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | L | 1-3 |
| NHL | 2019/11/17 00:00 | OTT Senators v BUF Sabres | W | 2-4 |
Home History
| NHL | 2022/11/16 00:00 | VAN Canucks v BUF Sabres | L | 5-4 |
| NHL | 2022/11/13 00:00 | BOS Bruins v BUF Sabres | L | 3-1 |
| NHL | 2022/11/11 00:00 | VGS Golden Knights v BUF Sabres | L | 7-4 |
| NHL | 2022/11/09 00:00 | ARZ Coyotes v BUF Sabres | L | 4-1 |
| NHL | 2022/11/05 23:00 | BUF Sabres v TB Lightning | L | 3-5 |
| NHL | 2022/11/04 23:00 | BUF Sabres v CAR Hurricanes | L | 3-5 |
| NHL | 2022/11/02 23:30 | PIT Penguins v BUF Sabres | W | 3-6 |
| NHL | 2022/10/31 23:00 | DET Red Wings v BUF Sabres | W | 3-8 |
Away History
| NHL | 2022/11/14 22:30 | NY Islanders v OTT Senators | L | 4-2 |
| NHL | 2022/11/12 18:00 | OTT Senators v PHI Flyers | W | 4-1 |
| NHL | 2022/11/11 00:00 | OTT Senators v NJ Devils | L | 3-4 |
| NHL | 2022/11/09 00:00 | VAN Canucks v OTT Senators | L | 6-4 |
| NHL | 2022/11/05 23:00 | PHI Flyers v OTT Senators | L | 2-1 |
| NHL | 2022/11/03 23:00 | VGS Golden Knights v OTT Senators | L | 5-4 |
| NHL | 2022/11/01 23:00 | OTT Senators v TB Lightning | L | 3-4 |
| NHL | 2022/10/29 20:00 | OTT Senators v FLA Panthers | L | 3-5 |