[16] STL Blues 2-6 BUF Sabres [26] 2022-11-24 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Craig Berube
Head to Head
| NHL | 2022/04/14 23:00 | STL Blues v BUF Sabres | W | 6-2 |
| NHL | 2022/02/26 01:00 | BUF Sabres v STL Blues | W | 3-5 |
| NHL | 2020/01/10 01:00 | BUF Sabres v STL Blues | W | 1-5 |
| NHL | 2019/12/11 00:30 | STL Blues v BUF Sabres | L | 2-5 |
| NHL | 2019/03/17 21:00 | STL Blues v BUF Sabres | L | 3-4 |
| NHL | 2018/12/28 01:00 | BUF Sabres v STL Blues | W | 1-4 |
| NHL | 2018/02/04 00:00 | STL Blues v BUF Sabres | W | 1-0 |
| NHL | 2017/12/11 00:00 | BUF Sabres v STL Blues | W | 2-3 |
Home History
| NHL | 2022/11/22 01:00 | ANA Ducks v STL Blues | W | 1-3 |
| NHL | 2022/11/20 01:00 | ANA Ducks v STL Blues | W | 2-6 |
| NHL | 2022/11/18 01:00 | WAS Capitals v STL Blues | W | 4-5 |
| NHL | 2022/11/17 00:30 | STL Blues v CHI Blackhawks | W | 5-2 |
| NHL | 2022/11/15 02:00 | STL Blues v COL Avalanche | W | 3-2 |
| NHL | 2022/11/13 03:00 | STL Blues v VGS Golden Knights | W | 3-2 |
| NHL | 2022/11/11 01:00 | SJ Sharks v STL Blues | W | 3-5 |
| NHL | 2022/11/09 00:00 | STL Blues v PHI Flyers | L | 1-5 |
Away History
| NHL | 2022/11/23 00:00 | BUF Sabres v MON Canadiens | W | 7-2 |
| NHL | 2022/11/20 00:00 | BUF Sabres v TOR Maple Leafs | L | 2-5 |
| NHL | 2022/11/17 00:00 | BUF Sabres v OTT Senators | L | 1-4 |
| NHL | 2022/11/16 00:00 | VAN Canucks v BUF Sabres | L | 5-4 |
| NHL | 2022/11/13 00:00 | BOS Bruins v BUF Sabres | L | 3-1 |
| NHL | 2022/11/11 00:00 | VGS Golden Knights v BUF Sabres | L | 7-4 |
| NHL | 2022/11/09 00:00 | ARZ Coyotes v BUF Sabres | L | 4-1 |
| NHL | 2022/11/05 23:00 | BUF Sabres v TB Lightning | L | 3-5 |