[10] PIT Penguins 4-3 BUF Sabres [24] 2022-12-10 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Sullivan
Head to Head
| NHL | 2022/11/02 23:30 | PIT Penguins v BUF Sabres | L | 3-6 |
| NHL Pre-Season | 2022/10/07 23:00 | BUF Sabres v PIT Penguins | W | 1-7 |
| NHL Pre-Season | 2022/10/01 17:00 | PIT Penguins v BUF Sabres | L | 1-3 |
| NHL | 2022/03/23 23:30 | PIT Penguins v BUF Sabres | L | 3-4 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | W | 2-3 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | L | 2-1 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | W | 4-5 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | W | 2-1 |
Home History
| NHL | 2022/12/07 00:00 | CLB Blue Jackets v PIT Penguins | W | 1-4 |
| NHL | 2022/12/04 00:00 | STL Blues v PIT Penguins | W | 2-6 |
| NHL | 2022/12/02 00:00 | VGS Golden Knights v PIT Penguins | W | 3-4 |
| NHL | 2022/11/30 00:00 | CAR Hurricanes v PIT Penguins | L | 3-2 |
| NHL | 2022/11/27 00:00 | TOR Maple Leafs v PIT Penguins | L | 4-1 |
| NHL | 2022/11/25 22:30 | PIT Penguins v PHI Flyers | W | 4-1 |
| NHL | 2022/11/24 00:00 | CAL Flames v PIT Penguins | W | 1-2 |
| NHL | 2022/11/21 00:00 | PIT Penguins v CHI Blackhawks | W | 5-3 |
Away History
| NHL | 2022/12/08 00:30 | BUF Sabres v CLB Blue Jackets | W | 9-4 |
| NHL | 2022/12/05 00:00 | SJ Sharks v BUF Sabres | W | 3-6 |
| NHL | 2022/12/02 00:00 | COL Avalanche v BUF Sabres | L | 6-4 |
| NHL | 2022/12/01 00:00 | BUF Sabres v DET Red Wings | W | 5-4 |
| NHL | 2022/11/29 00:00 | TB Lightning v BUF Sabres | L | 6-5 |
| NHL | 2022/11/26 01:00 | NJ Devils v BUF Sabres | L | 3-1 |
| NHL | 2022/11/24 00:00 | STL Blues v BUF Sabres | W | 2-6 |
| NHL | 2022/11/23 00:00 | BUF Sabres v MON Canadiens | W | 7-2 |