PIT Penguins 1-3 BUF Sabres 2022-10-01 17:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Sullivan
Head to Head
| NHL | 2022/03/23 23:30 | PIT Penguins v BUF Sabres | L | 3-4 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | W | 2-3 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | L | 2-1 |
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | W | 4-5 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | W | 2-1 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | W | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | W | 4-8 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | L | 2-4 |
Home History
| NHL Pre-Season | 2022/09/27 23:00 | DET Red Wings v PIT Penguins | L | 6-2 |
| NHL Pre-Season | 2022/09/25 23:00 | CLB Blue Jackets v PIT Penguins | L | 5-1 |
| NHL Pre-Season | 2022/09/25 17:00 | CLB Blue Jackets v PIT Penguins | W | 2-3 |
| NHL | 2022/05/15 23:00 | PIT Penguins v NY Rangers | L | 3-4 |
| NHL | 2022/05/13 23:00 | NY Rangers v PIT Penguins | L | 5-3 |
| NHL | 2022/05/11 23:00 | PIT Penguins v NY Rangers | L | 3-5 |
| NHL | 2022/05/09 23:00 | NY Rangers v PIT Penguins | W | 2-7 |
| NHL | 2022/05/07 23:00 | NY Rangers v PIT Penguins | W | 4-7 |
Away History
| NHL Pre-Season | 2022/09/28 23:00 | BUF Sabres v CLB Blue Jackets | L | 1-4 |
| NHL Pre-Season | 2022/09/27 23:00 | PHI Flyers v BUF Sabres | W | 1-2 |
| NHL Pre-Season | 2022/09/25 18:00 | BUF Sabres v WAS Capitals | W | 4-3 |
| NHL | 2022/04/29 23:00 | CHI Blackhawks v BUF Sabres | W | 2-3 |
| NHL | 2022/04/28 23:00 | BUF Sabres v BOS Bruins | L | 0-5 |
| NHL | 2022/04/23 16:30 | NY Islanders v BUF Sabres | W | 3-5 |
| NHL | 2022/04/21 23:00 | BUF Sabres v NJ Devils | W | 5-2 |
| NHL | 2022/04/17 21:00 | BUF Sabres v PHI Flyers | W | 5-3 |