| Colombia Regional League | 2021/10/18 17:00 | Estudiantes de Medellin v Politecnico J.I.C. | W | 2-1 |
| Colombia Regional League | 2022/07/03 21:24 | Estudiantes de Medellin v Atletico Nacional Medellin Reserves | L | 0-4 |
| Colombia Regional League | 2022/06/12 15:22 | Talento y Vida v Estudiantes de Medellin | W | 1-2 |
| Colombia Regional League | 2022/06/06 14:00 | Estudiantes de Medellin v Envigado FC Reserves | D | 0-0 |
| Colombia Regional League | 2022/05/30 19:29 | Estudiantes de Medellin v FC Leones Reserves | L | 0-2 |
| Colombia Regional League | 2022/05/24 15:00 | Medellin City FC v Estudiantes de Medellin | L | 5-2 |
| Colombia Regional League | 2022/05/09 14:00 | Lula FC v Estudiantes de Medellin | W | 2-3 |
| Colombia Regional League | 2022/04/11 16:00 | Estudiantes de Medellin v Real Santuario | D | 1-1 |
| Colombia Regional League | 2022/04/04 15:10 | Club Deportivo La Chalaca v Estudiantes de Medellin | L | 3-1 |
| Colombia Regional League | 2022/06/15 17:18 | Sol de Oriente v Politecnico J.I.C. | D | 0-0 |
| Colombia Regional League | 2022/05/24 17:12 | Real Santuario v Politecnico J.I.C. | L | 3-0 |
| Colombia Regional League | 2022/05/03 17:09 | Politecnico J.I.C. v Independiente Sabaneta | W | 3-1 |
| Colombia Regional League | 2022/04/25 16:18 | CD Gallegol v Politecnico J.I.C. | L | 2-1 |
| Colombia Regional League | 2022/03/18 14:10 | Medellin City FC v Politecnico J.I.C. | D | 0-0 |
| Colombia Regional League | 2022/03/02 15:13 | Aguilas Doradas Reserves v Politecnico J.I.C. | L | 2-0 |
| Colombia Regional League | 2021/11/12 23:10 | E.D.P IND. Medellin v Politecnico J.I.C. | L | 1-0 |
| Colombia Regional League | 2021/10/18 17:00 | Estudiantes de Medellin v Politecnico J.I.C. | L | 2-1 |