| Colombia Regional League | 2022/07/02 21:16 | Total Soccer FC v FC Leones Reserves | L | 3-2 |
| Colombia Regional League | 2022/05/30 19:29 | Estudiantes de Medellin v FC Leones Reserves | W | 0-2 |
| Colombia Regional League | 2022/05/24 15:00 | FC Leones Reserves v Atletico Nacional Medellin Reserves | W | 2-1 |
| Colombia Regional League | 2022/05/17 13:00 | Envigado FC Reserves v FC Leones Reserves | L | 4-0 |
| Colombia Regional League | 2022/04/23 17:18 | Real Santuario v FC Leones Reserves | D | 2-2 |
| Colombia Regional League | 2022/04/08 15:12 | FC Leones Reserves v Universidad de Antioquia | W | 3-2 |
| Colombia Regional League | 2022/02/28 16:29 | Molino Viejo v FC Leones Reserves | L | 2-0 |
| Colombia Regional League | 2021/11/29 16:00 | Independiente Sabaneta v FC Leones Reserves | W | 4-5 |
| Colombia Regional League | 2022/07/20 19:28 | Club Deportivo La Chalaca v Real Santuario | W | 4-2 |
| Colombia Regional League | 2022/07/02 19:15 | Club Deportivo La Chalaca v Deportivo Alexis Garcia | L | 0-4 |
| Colombia Regional League | 2022/05/27 15:00 | Club Deportivo La Chalaca v Medellin City FC | W | 4-1 |
| Colombia Regional League | 2022/05/16 15:10 | Club Deportivo La Chalaca v Molino Viejo | W | 4-1 |
| Colombia Regional League | 2022/04/25 14:16 | Lula FC v Club Deportivo La Chalaca | L | 6-1 |
| Colombia Regional League | 2022/04/11 15:13 | Club Deportivo La Chalaca v Aguilas Doradas Reserves | D | 1-1 |
| Colombia Regional League | 2022/04/04 15:10 | Club Deportivo La Chalaca v Estudiantes de Medellin | W | 3-1 |
| Colombia Regional League | 2022/03/23 17:14 | Club Deportivo La Chalaca v Sellos Colombianos | W | 2-1 |